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Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging
A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …
Diabetic nephropathy: challenges in pathogenesis, diagnosis, and treatment
Diabetic nephropathy (DN) is the leading cause of end‐stage renal disease worldwide.
Chronic hyperglycemia and high blood pressure are the main risk factors for the …
Chronic hyperglycemia and high blood pressure are the main risk factors for the …
Oxidative stress and diabetes: antioxidative strategies
Diabetes mellitus is one of the major public health problems worldwide. Considerable recent
evidence suggests that the cellular reduction-oxidation (redox) imbalance leads to oxidative …
evidence suggests that the cellular reduction-oxidation (redox) imbalance leads to oxidative …
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …
[HTML][HTML] Oxidative stress and NRF2/KEAP1/ARE pathway in diabetic kidney disease (DKD): new perspectives
Diabetes mellitus (DM) is one of the most debilitating chronic diseases worldwide, with
increased prevalence and incidence. In addition to its macrovascular damage, through its …
increased prevalence and incidence. In addition to its macrovascular damage, through its …
Klotho, oxidative stress, and mitochondrial damage in kidney disease
J Donate-Correa, B Martín-Carro, JB Cannata-Andía… - Antioxidants, 2023 - mdpi.com
Reducing oxidative stress stands at the center of a prevention and control strategy for
mitigating cellular senescence and aging. Kidney disease is characterized by a premature …
mitigating cellular senescence and aging. Kidney disease is characterized by a premature …
The role of advanced glycation end products in aging and metabolic diseases: bridging association and causality
Accumulation of advanced glycation end products (AGEs) on nucleotides, lipids, and
peptides/proteins are an inevitable component of the aging process in all eukaryotic …
peptides/proteins are an inevitable component of the aging process in all eukaryotic …
Bioactive compounds in oxidative stress-mediated diseases: targeting the NRF2/ARE signaling pathway and epigenetic regulation
Oxidative stress is a pathological condition occurring due to an imbalance between the
oxidants and antioxidant defense systems in the body. Nuclear factor E2-related factor 2 …
oxidants and antioxidant defense systems in the body. Nuclear factor E2-related factor 2 …
Oxidative stress: a culprit in the progression of diabetic kidney disease
Diabetic kidney disease (DKD) is the principal culprit behind chronic kidney disease (CKD),
ultimately develo** end-stage renal disease (ESRD) and necessitating costly dialysis or …
ultimately develo** end-stage renal disease (ESRD) and necessitating costly dialysis or …
Modulating NRF2 in disease: timing is everything
The transcription factor nuclear factor erythroid 2 (NF-E2)-related factor 2 (NRF2) is a central
regulator of redox, metabolic, and protein homeostasis that intersects with many other …
regulator of redox, metabolic, and protein homeostasis that intersects with many other …