Not all Salmonella enterica serovars cause the same disease. S. enterica represents an
incredibly diverse species comprising> 2,600 unique serovars. While some S. enterica …

Bacterial genotoxins (BTGX) induce DNA damage, which results in senescence or apoptosis
of the target cells if not properly repaired. Three BTGXs have been identified: the cytolethal …

Bacterial genotoxins damage host cells by targeting their chromosomal DNA. In the present
study, we demonstrate that a genotoxin of Salmonella Typhi, typhoid toxin, triggers the …

The pig industry is the principal source of meat products in China, and the presence of
pathogens in pig-borne meat is a crucial threat to public health. Salmonella is the major …

Fresh vegetables are closely associated with foodborne disease outbreaks; however,
systematic analysis of the microbiological quality of fresh vegetables and molecular …

Antimicrobial resistance is a global public health concern, and resistance genes in
Salmonella, especially those located on mobile genetic elements, are part of the problem …

Introduction Typhoid toxin-expressing Salmonella enterica causes DNA damage in the
intestinal mucosa in vivo, activating the DNA damage response (DDR) in the absence of …

Salmonella Typhi activates the host DNA damage response through the typhoid toxin,
facilitating typhoid symptoms and chronic infections. Here we reveal a non-canonical DNA …

ABSTRACT AB5-type toxins are a diverse family of protein toxins composed of an enzymatic
active (A) subunit and a pentameric delivery (B) subunit. Salmonella enterica serovar Typhi's …

Damage to our genomes triggers cellular senescence characterised by stable cell cycle
arrest and a pro-inflammatory secretome that prevents the unrestricted growth of cells with …