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Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions
Z Chen, F Han, Y Du, H Shi, W Zhou - Signal transduction and targeted …, 2023 - nature.com
Having a hypoxic microenvironment is a common and salient feature of most solid tumors.
Hypoxia has a profound effect on the biological behavior and malignant phenotype of …
Hypoxia has a profound effect on the biological behavior and malignant phenotype of …
Hypoxia signaling in human health and diseases: implications and prospects for therapeutics
Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …
HIF-1α drives resistance to ferroptosis in solid tumors by promoting lactate production and activating SLC1A1
Z Yang, W Su, X Wei, S Qu, D Zhao, J Zhou, Y Wang… - Cell reports, 2023 - cell.com
Solid tumors have developed robust ferroptosis resistance. The mechanism underlying
ferroptosis resistance regulation in solid tumors, however, remains elusive. Here, we report …
ferroptosis resistance regulation in solid tumors, however, remains elusive. Here, we report …
[HTML][HTML] Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation
CC Chen, W Tran, K Song, T Sugimoto, MB Obusan… - Cancer Cell, 2023 - cell.com
Trans-differentiation from an adenocarcinoma to a small cell neuroendocrine state is
associated with therapy resistance in multiple cancer types. To gain insight into the …
associated with therapy resistance in multiple cancer types. To gain insight into the …
Clinical and biological features of neuroendocrine prostate cancer
Y Yamada, H Beltran - Current oncology reports, 2021 - Springer
Abstract Purpose of Review Neuroendocrine prostate cancer (NEPC) is an aggressive
histologic subtype of prostate cancer that most commonly arises in later stages of prostate …
histologic subtype of prostate cancer that most commonly arises in later stages of prostate …
The role of lineage plasticity in prostate cancer therapy resistance
H Beltran, A Hruszkewycz, HI Scher… - Clinical cancer …, 2019 - aacrjournals.org
Lineage plasticity has emerged as an important mechanism of treatment resistance in
prostate cancer. Treatment-refractory prostate cancers are increasingly associated with loss …
prostate cancer. Treatment-refractory prostate cancers are increasingly associated with loss …
Molecular events in neuroendocrine prostate cancer development
Neuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer. NEPC arises
de novo only rarely; the disease predominantly develops from adenocarcinoma in response …
de novo only rarely; the disease predominantly develops from adenocarcinoma in response …