Doxorubicin‐induced cardiotoxicity: from bioenergetic failure and cell death to cardiomyopathy
FS Carvalho, A Burgeiro, R Garcia… - Medicinal research …, 2014 - Wiley Online Library
Doxorubicin (DOX) is an anticancer anthracycline that presents a dose‐dependent and
cumulative cardiotoxicity as one of the most serious side effects. Several hypotheses have …
cumulative cardiotoxicity as one of the most serious side effects. Several hypotheses have …
Cardiomyocyte death in doxorubicin-induced cardiotoxicity
Doxorubicin (DOX) is one of the most widely used and successful antitumor drugs, but its
cumulative and dose-dependent cardiac toxicity has been a major concern of oncologists in …
cumulative and dose-dependent cardiac toxicity has been a major concern of oncologists in …
Exercise preconditioning provides long-term protection against early chronic doxorubicin cardiotoxicity
DS Hydock, CY Lien, BT Jensen… - Integrative cancer …, 2011 - journals.sagepub.com
Acute doxorubicin (DOX) cardiotoxicity can be attenuated by exercise preconditioning, but
little is known of whether this cardioprotection continues beyond 10 days post-DOX …
little is known of whether this cardioprotection continues beyond 10 days post-DOX …
[HTML][HTML] Mitochondrial aldehyde dehydrogenase protects against doxorubicin cardiotoxicity through a transient receptor potential channel vanilloid 1-mediated …
Cardiotoxicity is one of the major life-threatening effects encountered in cancer
chemotherapy with doxorubicin and other anthracyclines. Mitochondrial aldehyde …
chemotherapy with doxorubicin and other anthracyclines. Mitochondrial aldehyde …
[HTML][HTML] Recent advances in the mechanisms of cell death and dysfunction in doxorubicin cardiotoxicity
Despite recent advances in cancer therapy, anthracycline-based combination therapy
remains the standardized first-line strategy and has been found to have effective antitumor …
remains the standardized first-line strategy and has been found to have effective antitumor …
Therapeutic concentrations of mitoxantrone elicit energetic imbalance in H9c2 cells as an earlier event
Mitoxantrone (MTX) is a chemotherapeutic agent that emerged as an alternative to
anthracycline therapy. However, MTX also causes late cardiotoxicity, being oxidative stress …
anthracycline therapy. However, MTX also causes late cardiotoxicity, being oxidative stress …
Antimony‐induced cardiomyopathy in guinea‐pig and protection by L‐carnitine
1 Antimony (Sb) is the mainstay for the treatment of Leishmaniasis. It has serious, often
lethal, cardiovascular side effects. The objective of this study was to examine the effects of …
lethal, cardiovascular side effects. The objective of this study was to examine the effects of …
Switching to a low-fat diet attenuates the intensified doxorubicin cardiotoxicity associated with high-fat feeding
DS Hydock, CY Lien, BT Jensen, CM Schneider… - Cancer chemotherapy …, 2013 - Springer
Purpose A high-fat diet has been shown to exacerbate the cardiotoxicity associated with the
chemotherapy drug doxorubicin (DOX); however, it is unknown whether switching from a …
chemotherapy drug doxorubicin (DOX); however, it is unknown whether switching from a …
Supplementation with l-carnitine does not reduce the efficacy of epirubicin treatment in breast cancer cells
CE Delaney, SP Hopkins, CL Addison - Cancer letters, 2007 - Elsevier
One of the cornerstones of therapy for invasive breast cancer includes the use of
anthracyclines. Epirubicin, a stereoisomer of doxorubicin, is one of the commonly used …
anthracyclines. Epirubicin, a stereoisomer of doxorubicin, is one of the commonly used …
[BOOK][B] Drug-induced cardiomyopathies
J Klimas - 2012 - researchgate.net
Heart failure represents one of most important causes of death in Western countries. Its high
mortality originates in part from severe complications like cardiac contractile dysfunction …
mortality originates in part from severe complications like cardiac contractile dysfunction …