A marked decrease in malaria-related deaths worldwide has been attributed to the
administration of effective antimalarials against Plasmodium falciparum, in particular …

Recent developments in synthetic biology, combined with continued progress in systems
biology and metabolic engineering, have enabled the engineering of microorganisms to …

Background Artemisinin resistance in Plasmodium falciparum has emerged in Southeast
Asia and now poses a threat to the control and elimination of malaria. Map** the …

Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens
malaria control and elimination activities worldwide. To monitor the spread of artemisinin …

Artemisinins are the cornerstone of anti-malarial drugs. Emergence and spread of resistance
to them,, raises risk of wi** out recent gains achieved in reducing worldwide malaria …

We report a large multicenter genome-wide association study of Plasmodium falciparum
resistance to artemisinin, the frontline antimalarial drug. Across 15 locations in Southeast …

The emergence of artemisinin resistance in Southeast Asia imperils efforts to reduce the
global malaria burden. We genetically modified the Plasmodium falciparum K13 locus using …

Summary Background Artemisinin resistance in Plasmodium falciparum lengthens parasite
clearance half-life during artemisinin monotherapy or artemisinin-based combination …

Understanding and controlling the spread of antimalarial resistance, particularly to
artemisinin and its partner drugs, is a top priority. Plasmodium falciparum parasites resistant …

Artemisinin resistance in Plasmodium falciparum threatens global efforts to control and
eliminate malaria. Polymorphisms in the kelch domain–carrying protein K13 are associated …