The human eosinophil has long been thought to favorably influence innate mucosal
immunity but at times has also been incriminated in disease pathophysiology. Research into …

Platelets are most often recognized for their crucial role in the control of acute hemorrhage.
However, current research has greatly expanded the appreciation of platelets beyond their …

Aeroallergen sensing by airway epithelial cells triggers pathogenic immune responses
leading to type 2 inflammation, the hallmark of chronic airway diseases such as asthma. Tuft …

Rationale: The mechanisms that underlie the pathogenesis of chronic rhinosinusitis without
nasal polyps (CRSsNP), chronic rhinosinusitis with nasal polyps (CRSwNP), and aspirin …

Aspirin-exacerbated respiratory disease (AERD) is characterized by the clinical triad of
chronic rhinosinusitis with nasal polyps, asthma, and an intolerance to medications that …

Leukotrienes (LTs) are lipid mediators that play pivotal roles in acute and chronic
inflammation and allergic diseases. They exert their biological effects by binding to specific …

The innate immune response to bacterial infections requires the interaction of neutrophils
and platelets. Here, we show that a multistep reciprocal crosstalk exists between these two …

Eosinophilic airway inflammation is one of the cardinal features of allergic airway diseases
such as atopic asthma and allergic rhinitis. These childhood‐onset conditions are mediated …

Background Dupilumab, a mAb targeting IL-4Rα, improves upper and lower airway
symptoms in patients with aspirin-exacerbated respiratory disease (AERD), but the …

Acute and chronic itch are burdensome manifestations of skin pathologies including allergic
skin diseases and atopic dermatitis, but the underlying molecular mechanisms are not well …