The predominantly animal-centric approach of chemical safety assessment has increasingly
come under pressure. Society is questioning overall performance, sustainability, continued …

New approach methodologies (NAMs) are increasingly being used for regulatory decision
making by agencies worldwide because of their potential to reliably and efficiently produce …

Drinking-water quality is a rising concern in the United States (US), emphasizing the need to
broadly assess exposures and potential health effects at the point-of-use. Drinking-water …

Image-based profiling is a maturing strategy by which the rich information present in
biological images is reduced to a multidimensional profile, a collection of extracted image …

Nontarget high-resolution mass spectrometry screening (NTS HRMS/MS) can detect
thousands of organic substances in environmental samples. However, new strategies are …

During the past few decades, the science of toxicology has been undergoing a
transformation from observational to predictive science. New approach methodologies …

Abstract New Approach Methodologies (NAMs) are considered to include any in vitro, in
silico or chemistry-based method, as well as the strategies to implement them, that may …

Purpose Reducing chemical pressure on human and environmental health is an integral
part of the global sustainability agenda. Guidelines for deriving globally applicable, life cycle …

Chemical risk assessments follow a long-standing paradigm that integrates hazard, dose–
response, and exposure information to facilitate quantitative risk characterization. Targeted …

Abstract Background New Approach Methodologies (NAMs) comprise in silico and in vitro
methods applied as alternative to animal testing. Even though NAMs are already fully …