Population genomic analyses of high-altitude humans and other vertebrates have identified
numerous candidate genes for hypoxia adaptation, and the physiological pathways …

To cope with the reduced availability of O2 at high altitude, air-breathing vertebrates have
evolved myriad adjustments in the cardiorespiratory system to match tissue O2 delivery with …

To investigate the predictability of genetic adaptation, we examined the molecular basis of
convergence in hemoglobin function in comparisons involving 56 avian taxa that have …

The deer mouse (genus Peromyscus) is the most abundant mammal in North America, and it
occupies almost every type of terrestrial habitat. It is not surprising therefore that the natural …

In air-breathing vertebrates at high altitude, fine-tuned adjustments in hemoglobin (Hb)–O2
affinity provide an energetically efficient means of mitigating the effects of arterial …

In mammals and other air-breathing vertebrates that live at high altitude, adjustments in
convective O 2 transport via changes in blood hemoglobin (Hb) content and/or Hb-O 2 …

Key points Mitochondrial function changes over time at high altitudes, but the potential
benefits of these changes for hypoxia resistance remains unclear. We used high‐altitude …

A fundamental question in evolutionary genetics concerns the extent to which adaptive
phenotypic convergence is attributable to convergent or parallel changes at the molecular …

Population genomic studies of humans and other animals at high altitude have generated
many hypotheses about the genes and pathways that may have contributed to hypoxia …

At high-altitude, small mammals are faced with the energetic challenge of sustaining
thermogenesis and aerobic exercise in spite of the reduced O2 availability. Under conditions …