Hydrazone comprising compounds as promising anti-infective agents: Chemistry and structure-property relationship

PC Sharma, D Sharma, A Sharma, N Saini… - Materials Today …, 2020 - Elsevier
Despite the adverse effects of microbial hazards on public health, major pharmaceutical
firms have left the field of anti-infective development and a dramatic reduction in the number …

Medicinal significance of benzothiazole scaffold: an insight view

PC Sharma, A Sinhmar, A Sharma… - Journal of enzyme …, 2013 - Taylor & Francis
Heterocycles bearing nitrogen, sulphur and thiazole moieties constitute the core structure of
a number of biologically interesting compounds. Benzothiazole, a group of xenobiotic …

Multicomponent and one‐pot syntheses of quinoxalines

L Biesen, TJJ Müller - Advanced Synthesis & Catalysis, 2021 - Wiley Online Library
Quinoxalines represent bicyclic nitrogen‐containing heterocycles with a wide array of
applications. They exhibit a multitude of biological activities relevant in medicinal chemistry …

An appraisal of anticancer activity with structure–activity relationship of quinazoline and quinazolinone analogues through EGFR and VEGFR inhibition: A review

K Haider, S Das, A Joseph… - Drug Development …, 2022 - Wiley Online Library
Cancer is one of the leading causes of death. Globally a huge number of deaths and new
incidences are reported annually. Heterocyclic compounds have been proved to be very …

Recent Development in Palladium-Catalyzed Domino Reactions: Access to Materials and Biologically Important Carbo-and Heterocycles

HA Dondas, MG Retamosa, JM Sansano - Organometallics, 2019 - ACS Publications
The chemistry of palladium complexes has no limits. Many domino processes (even
multicomponent) are continuously appearing in the literature. Carbocyclic and heterocyclic …

Recent progress on anti-Toxoplasma drugs discovery: Design, synthesis and screening

Y Deng, T Wu, SQ Zhai, CH Li - European journal of medicinal chemistry, 2019 - Elsevier
Toxoplasma gondii severely threaten the health of immunocompromised patients and
pregnant women as this parasite can cause several disease, including brain and eye …

Insights on fluoroquinolones in cancer therapy: Chemistry and recent developments

PC Sharma, R Goyal, A Sharma, D Sharma… - Materials Today …, 2020 - Elsevier
Cancer is a very risky life-threatening disease having most formidable afflictions in the world.
Several anticancer agents are commercially accessible, however, the emergence of …

Survey of recent literature related to the biologically active 4 (3H)-quinazolinones containing fused heterocycles

M Demeunynck, I Baussanne - Current medicinal chemistry, 2013 - ingentaconnect.com
the present review focuses on the synthesis and biological evaluation of polycyclic 4 (3H)-
quinazolinones containing fused aromatic or heteroaromatic rings. The first part of the …

Aryne and CO 2-based formal [2+ 2+ 2] annulation to access tetrahydroisoquinoline-fused benzoxazinones

S Liu, K Zhang, Y Meng, J Xu, N Chen - Organic & Biomolecular …, 2023 - pubs.rsc.org
Tetrahydroisoquinoline and its fused polyheterocycles are prevalent structural motifs found
in numerous natural products. In this study, we report a highly efficient and convergent …

Design, synthesis, biological evaluation of 6-(2-amino-1H-benzo [d] imidazole-6-yl) quinazolin-4 (3H)-one derivatives as novel anticancer agents with Aurora kinase …

C Fan, T Zhong, H Yang, Y Yang, D Wang… - European Journal of …, 2020 - Elsevier
Aurora A kinase, a member of the Aurora kinase family, is frequently overexpressed in
various human cancers. In addition, Overexpression of Aurora A kinase is associated with …