Tight junction proteins in gastrointestinal and liver disease
Over the past two decades a growing body of evidence has demonstrated an important role
of tight junction (TJ) proteins in the physiology and disease biology of GI and liver disease …
of tight junction (TJ) proteins in the physiology and disease biology of GI and liver disease …
Tight junction protein signaling and cancer biology
Tight junctions (TJs) are intercellular protein complexes that preserve tissue homeostasis
and integrity through the control of paracellular permeability and cell polarity. Recent …
and integrity through the control of paracellular permeability and cell polarity. Recent …
[HTML][HTML] Role of tight junctions in the epithelial-to-mesenchymal transition of cancer cells
D Kyuno, A Takasawa, S Kikuchi, I Takemasa… - … et Biophysica Acta (BBA …, 2021 - Elsevier
The epithelial-mesenchymal transition (EMT) is an essential step in cancer progression.
Epithelial cells possess several types of cell-cell junctions, and tight junctions are known to …
Epithelial cells possess several types of cell-cell junctions, and tight junctions are known to …
A Slee** Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis
Osteosarcomas are sarcomas of the bone, derived from osteoblasts or their precursors, with
a high propensity to metastasize. Osteosarcoma is associated with massive genomic …
a high propensity to metastasize. Osteosarcoma is associated with massive genomic …
The role and mechanism of claudins in cancer
DW Wang, WH Zhang, G Danil, K Yang, JK Hu - Frontiers in Oncology, 2022 - frontiersin.org
Claudins are a tetraspan membrane protein multigene family that plays a structural and
functional role in constructing tight junctions. Claudins perform crucial roles in maintaining …
functional role in constructing tight junctions. Claudins perform crucial roles in maintaining …
Claudin-18.2 as a therapeutic target in cancers: cumulative findings from basic research and clinical trials
D Kyuno, A Takasawa, K Takasawa, Y Ono… - Tissue …, 2022 - Taylor & Francis
Claudins are major components of tight junctions that maintain cell polarity and intercellular
adhesion. The dynamics of claudins in cancer cells have attracted attention as a therapeutic …
adhesion. The dynamics of claudins in cancer cells have attracted attention as a therapeutic …
Loss of claudin-3 expression induces IL6/gp130/Stat3 signaling to promote colon cancer malignancy by hyperactivating Wnt/β-catenin signaling
The hyperactivated Wnt/β-catenin signaling acts as a switch to induce epithelial to
mesenchymal transition and promote colorectal cancer. However, due to its essential role in …
mesenchymal transition and promote colorectal cancer. However, due to its essential role in …
Tight junction proteins and the biology of hepatobiliary disease
N Roehlen, AA Roca Suarez, H El Saghire… - International journal of …, 2020 - mdpi.com
Tight junctions (TJ) are intercellular adhesion complexes on epithelial cells and composed
of integral membrane proteins as well as cytosolic adaptor proteins. Tight junction proteins …
of integral membrane proteins as well as cytosolic adaptor proteins. Tight junction proteins …
[HTML][HTML] Claudins and hepatocellular carcinoma
W Wang, Y Zhou, W Li, C Quan, Y Li - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Hepatocellular carcinoma (HCC) has a high incidence and dismal prognosis, making it a
significant global health burden. To change this, the development of new therapeutic …
significant global health burden. To change this, the development of new therapeutic …
[HTML][HTML] ZDHHC12-mediated claudin-3 S-palmitoylation determines ovarian cancer progression
The membrane protein claudin-3 (CLDN3) is critical for the formation and maintenance of
tight junction and its high expression has been implicated in dictating malignant progression …
tight junction and its high expression has been implicated in dictating malignant progression …