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Fungal secondary metabolism: regulation, function and drug discovery
NP Keller - Nature Reviews Microbiology, 2019 - nature.com
One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …
Translating biosynthetic gene clusters into fungal armor and weaponry
NP Keller - Nature chemical biology, 2015 - nature.com
Filamentous fungi are renowned for the production of a diverse array of secondary
metabolites (SMs) where the genetic material required for synthesis of a SM is typically …
metabolites (SMs) where the genetic material required for synthesis of a SM is typically …
Natural compounds-based nanomedicines for cancer treatment: Future directions and challenges
T Andreani, R Cheng, K Elbadri, C Ferro… - Drug Delivery and …, 2024 - Springer
Several efforts have been extensively accomplished for the amelioration of the cancer
treatments using different types of new drugs and less invasives therapies in comparison …
treatments using different types of new drugs and less invasives therapies in comparison …
A call to arms: Mustering secondary metabolites for success and survival of an opportunistic pathogen
N Raffa, NP Keller - PLoS pathogens, 2019 - journals.plos.org
Aspergillus fumigatus is a ubiquitous saprophytic mold able to grow on a diversity of material
ranging from decayed organic matter in the environment to space station cupolas [1]. Yet this …
ranging from decayed organic matter in the environment to space station cupolas [1]. Yet this …
Detecting and prioritizing biosynthetic gene clusters for bioactive compounds in bacteria and fungi
Secondary metabolites (SM) produced by fungi and bacteria have long been of exceptional
interest owing to their unique biomedical ramifications. The traditional discovery of new …
interest owing to their unique biomedical ramifications. The traditional discovery of new …
Fragment-based covalent ligand screening enables rapid discovery of inhibitors for the RBR E3 ubiquitin ligase HOIP
H Johansson, YC Isabella Tsai, K Fantom… - Journal of the …, 2019 - ACS Publications
Modification of proteins with polyubiquitin chains is a key regulatory mechanism to control
cellular behavior and alterations in the ubiquitin system are linked to many diseases. Linear …
cellular behavior and alterations in the ubiquitin system are linked to many diseases. Linear …
The Aspergilli and Their Mycotoxins: Metabolic Interactions With Plants and the Soil Biota
Species of the highly diverse fungal genus Aspergillus are well-known agricultural pests,
and, most importantly, producers of various mycotoxins threatening food safety worldwide …
and, most importantly, producers of various mycotoxins threatening food safety worldwide …
Mesoporous zinc oxide-based drug delivery system offers an antifungal and immunoregulatory strategy for treating keratitis
L Gu, J Lin, Q Wang, F Meng, G Niu, H Lin… - Journal of Controlled …, 2024 - Elsevier
Fungal keratitis is a refractory eye disease that is prone to causing blindness. Fungal
virulence and inflammatory responses are two major factors that accelerate the course of …
virulence and inflammatory responses are two major factors that accelerate the course of …
The inconspicuous gatekeeper: endophytic Serendipita vermifera acts as extended plant protection barrier in the rhizosphere
D Sarkar, H Rovenich, G Jeena, S Nizam… - New …, 2019 - Wiley Online Library
In nature, beneficial and pathogenic fungi often simultaneously colonise plants. Despite
substantial efforts to understand the composition of natural plant− microbe communities, the …
substantial efforts to understand the composition of natural plant− microbe communities, the …
Secondary metabolite arsenal of an opportunistic pathogenic fungus
Aspergillus fumigatus is a versatile fungus able to successfully exploit diverse environments
from mammalian lungs to agricultural waste products. Among its many fitness attributes are …
from mammalian lungs to agricultural waste products. Among its many fitness attributes are …