Fungal secondary metabolism: regulation, function and drug discovery

NP Keller - Nature Reviews Microbiology, 2019 - nature.com
One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …

Translating biosynthetic gene clusters into fungal armor and weaponry

NP Keller - Nature chemical biology, 2015 - nature.com
Filamentous fungi are renowned for the production of a diverse array of secondary
metabolites (SMs) where the genetic material required for synthesis of a SM is typically …

Natural compounds-based nanomedicines for cancer treatment: Future directions and challenges

T Andreani, R Cheng, K Elbadri, C Ferro… - Drug Delivery and …, 2024 - Springer
Several efforts have been extensively accomplished for the amelioration of the cancer
treatments using different types of new drugs and less invasives therapies in comparison …

A call to arms: Mustering secondary metabolites for success and survival of an opportunistic pathogen

N Raffa, NP Keller - PLoS pathogens, 2019 - journals.plos.org
Aspergillus fumigatus is a ubiquitous saprophytic mold able to grow on a diversity of material
ranging from decayed organic matter in the environment to space station cupolas [1]. Yet this …

Detecting and prioritizing biosynthetic gene clusters for bioactive compounds in bacteria and fungi

PN Tran, MR Yen, CY Chiang, HC Lin… - Applied microbiology and …, 2019 - Springer
Secondary metabolites (SM) produced by fungi and bacteria have long been of exceptional
interest owing to their unique biomedical ramifications. The traditional discovery of new …

Fragment-based covalent ligand screening enables rapid discovery of inhibitors for the RBR E3 ubiquitin ligase HOIP

H Johansson, YC Isabella Tsai, K Fantom… - Journal of the …, 2019 - ACS Publications
Modification of proteins with polyubiquitin chains is a key regulatory mechanism to control
cellular behavior and alterations in the ubiquitin system are linked to many diseases. Linear …

The Aspergilli and Their Mycotoxins: Metabolic Interactions With Plants and the Soil Biota

WP Pfliegler, I Pócsi, Z Győri, T Pusztahelyi - Frontiers in microbiology, 2020 - frontiersin.org
Species of the highly diverse fungal genus Aspergillus are well-known agricultural pests,
and, most importantly, producers of various mycotoxins threatening food safety worldwide …

Mesoporous zinc oxide-based drug delivery system offers an antifungal and immunoregulatory strategy for treating keratitis

L Gu, J Lin, Q Wang, F Meng, G Niu, H Lin… - Journal of Controlled …, 2024 - Elsevier
Fungal keratitis is a refractory eye disease that is prone to causing blindness. Fungal
virulence and inflammatory responses are two major factors that accelerate the course of …

The inconspicuous gatekeeper: endophytic Serendipita vermifera acts as extended plant protection barrier in the rhizosphere

D Sarkar, H Rovenich, G Jeena, S Nizam… - New …, 2019 - Wiley Online Library
In nature, beneficial and pathogenic fungi often simultaneously colonise plants. Despite
substantial efforts to understand the composition of natural plant− microbe communities, the …

Secondary metabolite arsenal of an opportunistic pathogenic fungus

E Bignell, TC Cairns… - … of the Royal …, 2016 - royalsocietypublishing.org
Aspergillus fumigatus is a versatile fungus able to successfully exploit diverse environments
from mammalian lungs to agricultural waste products. Among its many fitness attributes are …