Increased IGFBP proteolysis, IGF-I bioavailability, and pappalysin levels in children with prader-willi syndrome
Abstract Context Prader-Willi syndrome (PWS) is associated with impaired growth hormone
(GH) secretion and decreased insulin-like growth factor (IGF)-I levels. Pappalysins (PAPP-A …
(GH) secretion and decreased insulin-like growth factor (IGF)-I levels. Pappalysins (PAPP-A …
Growth hormone/insulin-like growth factor I axis in health and disease states: an update on the role of intra-portal insulin
KCJ Yuen, R Hjortebjerg, AA Ganeshalingam… - Frontiers in …, 2024 - frontiersin.org
Growth hormone (GH) is the key regulator of insulin-like growth factor I (IGF-I) generation in
healthy states. However, portal insulin delivery is also an essential co-player in the …
healthy states. However, portal insulin delivery is also an essential co-player in the …
[HTML][HTML] A case of ulcerative colitis associated with teprotumumab treatment for thyroid eye disease
MB Safo, RZ Silkiss - American Journal of Ophthalmology Case Reports, 2021 - Elsevier
Purpose To present a case of ulcerative colitis associated with teprotumumab treatment for
thyroid eye disease. Observations A 46-year-old Indian female was treated with …
thyroid eye disease. Observations A 46-year-old Indian female was treated with …
[HTML][HTML] Relationship between IGF-1 and body weight in inflammatory bowel diseases: Cellular and molecular mechanisms involved
LG Guijarro, D Cano-Martínez, MV Toledo-Lobo… - Biomedicine & …, 2021 - Elsevier
Inflammatory bowel diseases (IBD), represented by ulcerative colitis (UC) and Crohn's
disease (CD), are characterized by chronic inflammation of the gastrointestinal tract, what …
disease (CD), are characterized by chronic inflammation of the gastrointestinal tract, what …
The IGF–PAPP-A–Stanniocalcin Axis in Serum and Ascites Associates with Prognosis in Patients with Ovarian Cancer
R Hjortebjerg, C Høgdall, KH Hansen… - International Journal of …, 2024 - mdpi.com
Pregnancy-associated plasma protein-A (PAPP-A) and PAPP-A2 modulate insulin-like
growth factor (IGF) action and are inhibited by the stanniocalcins (STC1 and STC2). We …
growth factor (IGF) action and are inhibited by the stanniocalcins (STC1 and STC2). We …
Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2
Q Zhong, H Chu, G Wang, C Zhang, R Li, F Guo… - Cell Discovery, 2022 - nature.com
Originally discovered in the circulation of pregnant women as a protein secreted by
placental trophoblasts, the metalloprotease pregnancy-associated plasma protein A (PAPP …
placental trophoblasts, the metalloprotease pregnancy-associated plasma protein A (PAPP …
Heritability and circulating concentrations of pregnancy-associated plasma protein-A and stanniocalcin-2 in elderly monozygotic and dizygotic twins
R Hjortebjerg, DA Pedersen, J Mengel-From… - Frontiers in …, 2023 - frontiersin.org
Introduction Pregnancy-associated plasma protein-A (PAPP-A) is an IGF-activating enzyme
suggested to influence aging-related diseases. However, knowledge on serum PAPP-A …
suggested to influence aging-related diseases. However, knowledge on serum PAPP-A …
Decoding Cytokine Networks in Ulcerative Colitis to Identify Pathogenic Mechanisms and Therapeutic Targets
ML Olbei, I Hautefort, JP Thomas, LL Csabai, B Bogar… - bioRxiv, 2024 - biorxiv.org
Ulcerative colitis (UC) is a chronic inflammatory disorder of the gastrointestinal tract
characterised by dysregulated cytokine signalling. Despite the advent of advanced therapies …
characterised by dysregulated cytokine signalling. Despite the advent of advanced therapies …
Local IGF bioactivity associates with high PAPP-a activity in the pericardial cavity of cardiovascular disease patients
Objective Pregnancy-associated plasma protein-A (PAPP-A) has been suggested as a
proatherogenic enzyme by its ability to locally increase insulin-like growth factor (IGF) …
proatherogenic enzyme by its ability to locally increase insulin-like growth factor (IGF) …
Pregnancy-associated plasma Protein-A2 is associated with mortality in patients with lung cancer
Pregnancy-associated plasma protein-A (PAPP-A) and its homolog PAPP-A2 are enzymes
that modulate the availability and mitogenic activity of insulin-like growth factor-I (IGF-I) …
that modulate the availability and mitogenic activity of insulin-like growth factor-I (IGF-I) …