Harnessing immunoinformatics for precision vaccines: designing epitope-based subunit vaccines against hepatitis E virus
Background/Objectives: Hepatitis E virus (HEV) is an RNA virus recognized to be spread
mainly by fecal-contaminated water. Its infection is known to be a serious threat to public …
mainly by fecal-contaminated water. Its infection is known to be a serious threat to public …
[HTML][HTML] In silico structural and functional annotation of hypothetical proteins of Vibrio cholerae O139
In develo** countries threat of cholera is a significant health concern whenever water
purification and sewage disposal systems are inadequate. Vibrio cholerae is one of the …
purification and sewage disposal systems are inadequate. Vibrio cholerae is one of the …
In Silico Screening of Isocitrate Lyase for Novel Anti-Buruli Ulcer Natural Products Originating from Africa
Buruli ulcer (BU) is caused by Mycobacterium ulcerans and is predominant in both tropical
and subtropical regions. The neglected debilitating disease is characterized by chronic …
and subtropical regions. The neglected debilitating disease is characterized by chronic …
Molecular-docking study of malaria drug target enzyme transketolase in Plasmodium falciparum 3D7 portends the novel approach to its treatment
Background Malaria has been a major life threatening mosquito borne disease from long
since. Unavailability of any effective vaccine and recent emergence of multi drug resistant …
since. Unavailability of any effective vaccine and recent emergence of multi drug resistant …
A comprehensive immunoinformatics and target site study revealed the corner-stone toward Chikungunya virus treatment
Recent concerning facts of Chikungunya virus (CHIKV); a Togaviridae family alphavirus has
proved this as a worldwide emerging threat which causes Chikungunya fever and …
proved this as a worldwide emerging threat which causes Chikungunya fever and …
Synthesis, in vitro α-glucosidase, α-amylase inhibitory potential and molecular docking study of thiadiazole-sulfonamide hybrid analogues
We have synthesized fourteen thiadiazole-sulfonamide hybrid analogues (1–14),
characterized throygh different technequies ie, NMR, HR-EIMS, and screened against α …
characterized throygh different technequies ie, NMR, HR-EIMS, and screened against α …
Identification of putative drug targets in Vancomycin-resistant Staphylococcus aureus (VRSA) using computer aided protein data analysis
Vancomycin-resistant Staphylococcus aureus (VRSA) is a Gram-positive, facultative aerobic
bacterium which is evolved from the extensive exposure of Vancomycin to Methicillin …
bacterium which is evolved from the extensive exposure of Vancomycin to Methicillin …
Binding free energy calculations of nine FDA‐approved protease inhibitors against HIV‐1 subtype C I36T↑ T containing 100 amino acids per monomer
HA Lockhat, JRA Silva, CN Alves… - Chemical biology & …, 2016 - Wiley Online Library
In this work, have investigated the binding affinities of nine FDA‐approved protease inhibitor
drugs against a new HIV‐1 subtype C mutated protease, I36T↑ T. Without an X‐ray crystal …
drugs against a new HIV‐1 subtype C mutated protease, I36T↑ T. Without an X‐ray crystal …
Structure and function insights garnered from in silico modeling of the thrombospondin type‐1 domain‐containing 7A antigen
SV Stoddard, CL Welsh, MM Palopoli… - Proteins: Structure …, 2019 - Wiley Online Library
The thrombospondin type‐1 domain containing 7A (THSD7A) protein is known to be one of
the antigens responsible for the autoimmune disorder idiopathic membranous nephropathy …
the antigens responsible for the autoimmune disorder idiopathic membranous nephropathy …
Computational Analysis and Binding Site Identification of Type III Secretion System ATPase from Pseudomonas aeruginosa
In many gram-negative bacteria, the type III secretion system (T3SS), as a virulence factor, is
an attractive target for develo** novel antibacterial. Regarding this, in our study, we aimed …
an attractive target for develo** novel antibacterial. Regarding this, in our study, we aimed …