The chemokine CXCL8 has been found to play an important role in tumor progression in
recent years. CXCL8 activates multiple intracellular signaling pathways by binding to its …

Esophageal squamous cell carcinoma (ESCC), is the most common type of esophageal
cancer worldwide, mainly occurring in the Asian esophageal cancer belt, including northern …

Drug resistance remains the major obstacle limiting the effectiveness of chemotherapy for
esophageal squamous cell carcinoma (ESCC)[1]. However, how stromal cells cooperate …

We sought to identify tumor-secreted factors that altered the frequency of MDSCs and
correlated with clinical outcomes in advanced melanoma patients. We focused our study on …

Esophageal cancer (EC) is one of the most life-threatening malignancies worldwide.
Esophageal squamous cell carcinoma (ESCC) is the dominant subtype, accounting for …

Cancer-associated fibroblasts (CAFs) plays an important role in the tumor
microenvironment. The heterogeneity of CAFs affects the effect of CAFs on promoting or …

Cancer‐associated fibroblasts (CAF) are a heterogeneous cell population within the tumor
microenvironment, and play an important role in tumor development. By regulating the …

As a highly invasive malignancy, esophageal cancer (EC) is a global health issue, and was
the eighth most prevalent cancer and the sixth leading cause of cancer-related death …

Abstract Tryptophan 2, 3-dioxygnease 2 (TDO2) is specific for metabolizing tryptophan to
kynurenine (KYN), which plays a critical role in mediating immune escape of cancer …

Background Patients with cancer rely on morphine for analgesia, while studies have
indicated morphine can induce immunosuppression in cancer. Therefore, investigating the …