What are white matter hyperintensities made of? Relevance to vascular cognitive impairment

JM Wardlaw, MC Valdés Hernández… - Journal of the …, 2015 - ahajournals.org
White matter hyperintensities (WMH) of presumed vascular origin, also referred to as
leukoaraiosis, are a very common finding on brain magnetic resonance imaging (MRI) or …

The importance of comorbidities in ischemic stroke: Impact of hypertension on the cerebral circulation

MJ Cipolla, DS Liebeskind… - Journal of Cerebral Blood …, 2018 - journals.sagepub.com
Comorbidities are a hallmark of stroke that both increase the incidence of stroke and worsen
outcome. Hypertension is prevalent in the stroke population and the most important …

Challenging the ischemic core concept in acute ischemic stroke imaging

M Goyal, JM Ospel, B Menon, M Almekhlafi… - Stroke, 2020 - ahajournals.org
Endovascular treatment is a highly effective therapy for acute ischemic stroke due to large
vessel occlusion and has recently revolutionized stroke care. Oftentimes, ischemic core …

Cerebral collateral circulation in the era of reperfusion therapies for acute ischemic stroke

SM Uniken Venema, JW Dankbaar, A van der Lugt… - Stroke, 2022 - ahajournals.org
Clinical outcomes of patients with acute ischemic stroke depend in part on the extent of their
collateral circulation. A good collateral circulation has also been associated with greater …

WMH and long-term outcomes in ischemic stroke: a systematic review and meta-analysis

MK Georgakis, M Duering, JM Wardlaw, M Dichgans - Neurology, 2019 - neurology.org
Objective To investigate the relationship between baseline white matter hyperintensities
(WMH) in patients with ischemic stroke and long-term risk of dementia, functional …

Damaging effects of a high-fat diet to the brain and cognition: a review of proposed mechanisms

LR Freeman, V Haley-Zitlin… - Nutritional …, 2014 - Taylor & Francis
The prevalence of obesity is growing and now includes at least one-third of the adult
population in the United States. As obesity and dementia rates reach epidemic proportions …

Cerebral white matter: neuroanatomy, clinical neurology, and neurobehavioral correlates

JD Schmahmann, EE Smith, FS Eichler… - Annals of the New …, 2008 - Wiley Online Library
Lesions of the cerebral white matter (WM) result in focal neurobehavioral syndromes,
neuropsychiatric phenomena, and dementia. The cerebral WM contains fiber pathways that …

Stroke outcomes are worse with larger leukoaraiosis volumes

WS Ryu, SH Woo, D Schellingerhout, MU Jang… - Brain, 2017 - academic.oup.com
Leukoaraiosis or white matter hyperintensities are frequently observed on magnetic
resonance imaging of stroke patients. We investigated how white matter hyperintensity …

Clinically confirmed stroke with negative diffusion-weighted imaging magnetic resonance imaging: longitudinal study of clinical outcomes, stroke recurrence, and …

SDJ Makin, FN Doubal, MS Dennis, JM Wardlaw - Stroke, 2015 - ahajournals.org
Background and Purpose—We sought to establish whether the presence (versus absence)
of a lesion on magnetic resonance imaging (MRI) with diffusion weighting (DWI-MRI) at …

Severity of leukoaraiosis correlates with clinical outcome after ischemic stroke

EM Arsava, R Rahman, J Rosand, J Lu, EE Smith… - Neurology, 2009 - neurology.org
Background: Leukoaraiosis (LA) is closely associated with aging, a major determinant of
clinical outcome after ischemic stroke. In this study we sought to identify whether LA …