Ring opening polymerization of α-amino acids: advances in synthesis, architecture and applications of polypeptides and their hybrids
Polypeptides have attracted considerable attention in recent decades due to their inherent
biodegradability and tunable cytocompatibility. Macromolecular design in conjunction with …
biodegradability and tunable cytocompatibility. Macromolecular design in conjunction with …
Host defense peptide mimicking antimicrobial amino acid polymers and beyond: Design, synthesis and biomedical applications
Microbial infections endanger human health and life. Conventional antibiotics has saved
countless human lives, however, is seriously challenged by the quick emergence of …
countless human lives, however, is seriously challenged by the quick emergence of …
Tumor extravasation and infiltration as barriers of nanomedicine for high efficacy: The current status and transcytosis strategy
Nanotechnology-based drug delivery platforms have been explored for cancer treatments
and resulted in several nanomedicines in clinical uses and many in clinical trials. However …
and resulted in several nanomedicines in clinical uses and many in clinical trials. However …
[HTML][HTML] Polymer bioconjugates: Modern design concepts toward precision hybrid materials
The conjugation of synthetic polymers with various biomolecules provides an easy access to
biohybrid materials which combine advantages from both the synthetic world and Nature …
biohybrid materials which combine advantages from both the synthetic world and Nature …
A moisture-tolerant route to unprotected α/β-amino acid N-carboxyanhydrides and facile synthesis of hyperbranched polypeptides
A great hurdle in the production of synthetic polypeptides lies in the access of N-
carboxyanhydrides (NCA) monomers, which requires dry solvents, Schlenk line/gloveboxe …
carboxyanhydrides (NCA) monomers, which requires dry solvents, Schlenk line/gloveboxe …
Chemical approaches to synthetic drug delivery systems for systemic applications
D Braatz, M Cherri, M Tully, M Dimde… - Angewandte Chemie …, 2022 - Wiley Online Library
Poor water solubility and low bioavailability of active pharmaceutical ingredients (APIs) are
major causes of friction in the pharmaceutical industry and represent a formidable hurdle for …
major causes of friction in the pharmaceutical industry and represent a formidable hurdle for …
Lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N-carboxyanhydrides
Polypeptides have broad applications and can be prepared via ring-opening polymerization
of α-amino acid N-carboxyanhydrides (NCAs). Conventional initiators, such as primary …
of α-amino acid N-carboxyanhydrides (NCAs). Conventional initiators, such as primary …
[HTML][HTML] An immunomodulatory polypeptide hydrogel for osteochondral defect repair
M Yang, ZC Zhang, FZ Yuan, RH Deng, X Yan… - Bioactive Materials, 2023 - Elsevier
Osteochondral injury is a common and frequent orthopedic disease that can lead to more
serious degenerative joint disease. Tissue engineering is a promising modality for …
serious degenerative joint disease. Tissue engineering is a promising modality for …
Recent advances in anti-cancer protein/peptide delivery
X Liu, F Wu, Y Ji, L Yin - Bioconjugate chemistry, 2018 - ACS Publications
Protein/peptide drugs possess unique advantages, such as high pharmacological potency,
molecular specificity, multifunctionality, and low toxicity, and thus hold great potential for use …
molecular specificity, multifunctionality, and low toxicity, and thus hold great potential for use …
Secondary structures in synthetic polypeptides from N-carboxyanhydrides: design, modulation, association, and material applications
Synthetic polypeptides derived from the ring-opening polymerization of N-
carboxyanhydrides can spontaneously fold into stable secondary structures under specific …
carboxyanhydrides can spontaneously fold into stable secondary structures under specific …