Mechanisms of oxidative stress in metabolic syndrome
Metabolic syndrome is a cluster of conditions associated with the risk of diabetes mellitus
type 2 and cardiovascular diseases (CVDs). Metabolic syndrome is closely related to …
type 2 and cardiovascular diseases (CVDs). Metabolic syndrome is closely related to …
Endoplasmic reticulum stress and associated ROS
HMA Zeeshan, GH Lee, HR Kim, HJ Chae - International journal of …, 2016 - mdpi.com
The endoplasmic reticulum (ER) is a fascinating network of tubules through which secretory
and transmembrane proteins enter unfolded and exit as either folded or misfolded proteins …
and transmembrane proteins enter unfolded and exit as either folded or misfolded proteins …
[HTML][HTML] Redox signaling and unfolded protein response coordinate cell fate decisions under ER stress
Endoplasmic reticulum (ER) is a dynamic organelle orchestrating the folding and post-
translational maturation of almost all membrane proteins and most secreted proteins. These …
translational maturation of almost all membrane proteins and most secreted proteins. These …
IRE1: ER stress sensor and cell fate executor
Y Chen, F Brandizzi - Trends in cell biology, 2013 - cell.com
Cells operate a signaling network termed the unfolded protein response (UPR) to monitor
protein-folding capacity in the endoplasmic reticulum (ER). Inositol-requiring enzyme 1 …
protein-folding capacity in the endoplasmic reticulum (ER). Inositol-requiring enzyme 1 …
The unfolded protein response: detecting and responding to fluctuations in the protein-folding capacity of the endoplasmic reticulum
Most of the secreted and plasma membrane proteins are synthesized on membrane-bound
ribosomes on the endoplasmic reticulum (ER). They require engagement of ER-resident …
ribosomes on the endoplasmic reticulum (ER). They require engagement of ER-resident …
Upstream open reading frames differentially regulate gene-specific translation in the integrated stress response
SK Young, RC Wek - Journal of Biological Chemistry, 2016 - ASBMB
Translation regulation largely occurs during initiation, which features ribosome assembly
onto mRNAs and selection of the translation start site. Short, upstream ORFs (uORFs) …
onto mRNAs and selection of the translation start site. Short, upstream ORFs (uORFs) …
Oxidative stress and neurodegenerative disorders
J Li, WO, W Li, ZG Jiang, HA Ghanbari - International journal of molecular …, 2013 - mdpi.com
Living cells continually generate reactive oxygen species (ROS) through the respiratory
chain during energetic metabolism. ROS at low or moderate concentration can play …
chain during energetic metabolism. ROS at low or moderate concentration can play …
[HTML][HTML] Metabolism, toxicity and anticancer activities of arsenic compounds
I Khairul, QQ Wang, YH Jiang, C Wang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
A variety of studies indicated that inorganic arsenic and its methylated metabolites have
paradoxical effects, namely, carcinogenic and anticancer effects. Epidemiological studies …
paradoxical effects, namely, carcinogenic and anticancer effects. Epidemiological studies …
Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation
Misdirected immunity gives rise to the autoimmune tissue inflammation of rheumatoid
arthritis, in which excess production of the cytokine tumor necrosis factor (TNF) is a central …
arthritis, in which excess production of the cytokine tumor necrosis factor (TNF) is a central …
[HTML][HTML] The role of MAPK signalling pathways in the response to endoplasmic reticulum stress
Perturbations in endoplasmic reticulum (ER) homeostasis, including depletion of Ca 2+ or
altered redox status, induce ER stress due to protein accumulation, misfolding and …
altered redox status, induce ER stress due to protein accumulation, misfolding and …