Bisphosphonate-related osteonecrosis of the jaw (BRONJ) has generated great interest in
the medical and research communities yet remains an enigma, given its unknown …

The bisphosphonates (BPs) have been useful tools in our understanding of the role that
bone remodeling plays in skeletal health. The purpose of this paper is to outline what we …

The classic sequence in the pathogenesis of osteoradionecrosis of the jaws has been
accepted as radiation, trauma, and infection. This paper challenges this sequence and offers …

Bisphosphonates (BPs) are medications used commonly to treat primary and metastatic
bone cancer, as well as osteoporosis. Although BPs improve bone mineral density, reduce …

One year of high-dose bisphosphonate (BPs) therapy in dogs allowed the increased
accumulation of advanced glycation end-products (AGEs) and reduced postyield work-to …

Large animal models are required for preclinical prevention and intervention studies related
to osteoporosis research. The challenging aspect of this requirement is that no single animal …

The goal of this study was to characterize longitudinal changes in bone microarchitecture
and function in women treated with an established antifracture therapeutic. In this double …

OBJECTIVE: The purpose of this study was to test the effects of bisphosphonates on
osteoblast viability and function. STUDY DESIGN: Primary rat osteoblasts were cultured in …

Structured Abstract Authors–Burr DB, Allen MR Objectives–To test the effect of
bisphosphonate (BP) treatment for up to 3 years on bone necrosis and osteocyte death in …

Reduced bone toughness, the energy absorption capacity of the tissue, has been
consistently documented in vertebrae of animals treated with a wide range of …