Root of the tree: the significance, evolution, and origins of the ribosome

JC Bowman, AS Petrov, M Frenkel-Pinter… - Chemical …, 2020 - ACS Publications
The ribosome is an ancient molecular fossil that provides a telescope to the origins of life.
Made from RNA and protein, the ribosome translates mRNA to coded protein in all living …

[HTML][HTML] The nucleolus under stress

S Boulon, BJ Westman, S Hutten, FM Boisvert… - Molecular cell, 2010 - cell.com
Cells typically respond quickly to stress, altering their metabolism to compensate. In
mammalian cells, stress signaling usually leads to either cell-cycle arrest or apoptosis …

Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells

EJ Grow, RA Flynn, SL Chavez, NL Bayless… - Nature, 2015 - nature.com
Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections, and comprise
nearly 8% of the human genome. The most recently acquired human ERV is HERVK (HML …

MYC as a regulator of ribosome biogenesis and protein synthesis

J Van Riggelen, A Yetil, DW Felsher - Nature Reviews Cancer, 2010 - nature.com
MYC regulates the transcription of thousands of genes required to coordinate a range of
cellular processes, including those essential for proliferation, growth, differentiation …

Activation of mTORC2 by association with the ribosome

V Zinzalla, D Stracka, W Oppliger, MN Hall - Cell, 2011 - cell.com
The target of rapamycin (TOR) is a highly conserved protein kinase and a central controller
of growth. Mammalian TOR complex 2 (mTORC2) regulates AGC kinase family members …

High-Resolution Profiling of a Synchronized Diurnal Transcriptome from Chlamydomonas reinhardtii Reveals Continuous Cell and Metabolic Differentiation

JM Zones, IK Blaby, SS Merchant, JG Umen - The Plant Cell, 2015 - academic.oup.com
The green alga Chlamydomonas reinhardtii is a useful model organism for investigating
diverse biological processes, such as photosynthesis and chloroplast biogenesis, flagella …

How common are extraribosomal functions of ribosomal proteins?

JR Warner, KB McIntosh - Molecular cell, 2009 - cell.com
Ribosomal proteins are ubiquitous, abundant, and RNA binding: prime candidates for
recruitment to extraribosomal functions. Indeed, they participate in balancing the synthesis of …

Tumor‐adjacent tissue co‐expression profile analysis reveals pro‐oncogenic ribosomal gene signature for prognosis of resectable hepatocellular carcinoma

OV Grinchuk, SP Yenamandra, R Iyer… - Molecular …, 2018 - Wiley Online Library
Currently, molecular markers are not used when determining the prognosis and treatment
strategy for patients with hepatocellular carcinoma (HCC). In the present study, we proposed …

Ribosome biogenesis: emerging evidence for a central role in the regulation of skeletal muscle mass

T Chaillou, TJ Kirby, JJ McCarthy - Journal of cellular …, 2014 - Wiley Online Library
The ribosome is a supramolecular ribonucleoprotein complex that functions at the heart of
the translation machinery to convert mRNA into protein. Ribosome biogenesis is the primary …

Role of ribosomal protein mutations in tumor development

KM Goudarzi, MS LINDSTRöM - … journal of oncology, 2016 - spandidos-publications.com
Ribosomes are cellular machines essential for protein synthesis. The biogenesis of
ribosomes is a highly complex and energy consuming process that initiates in the nucleolus …