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Neuroimmunology of traumatic brain injury: time for a paradigm shift
Traumatic brain injury (TBI) is a leading cause of morbidity and disability, with a
considerable socioeconomic burden. Heterogeneity of pathoanatomical subtypes and …
considerable socioeconomic burden. Heterogeneity of pathoanatomical subtypes and …
Pathophysiology and treatment of cerebral edema in traumatic brain injury
RM Jha, PM Kochanek, JM Simard - Neuropharmacology, 2019 - Elsevier
Cerebral edema (CE) and resultant intracranial hypertension are associated with
unfavorable prognosis in traumatic brain injury (TBI). CE is a leading cause of in-hospital …
unfavorable prognosis in traumatic brain injury (TBI). CE is a leading cause of in-hospital …
Roles of peroxisome proliferator-activated receptor gamma on brain and peripheral inflammation
Peroxisome proliferator-activated receptor gamma (PPARγ) has been implicated in the
pathology of numerous diseases involving diabetes, stroke, cancer, or obesity. It is …
pathology of numerous diseases involving diabetes, stroke, cancer, or obesity. It is …
Current understanding of neuroinflammation after traumatic brain injury and cell-based therapeutic opportunities
Traumatic brain injury (TBI) remains a major cause of death and disability worldwide.
Increasing evidence indicates that TBI is an important risk factor for neurodegenerative …
Increasing evidence indicates that TBI is an important risk factor for neurodegenerative …
MicroRNA-based therapeutics in central nervous system injuries
Central nervous system (CNS) injuries, such as stroke, traumatic brain injury (TBI) and
spinal cord injury (SCI), are important causes of death and long-term disability worldwide …
spinal cord injury (SCI), are important causes of death and long-term disability worldwide …
Single-cell transcriptomics reveals functionally specialized vascular endothelium in brain
The blood-brain barrier (BBB) limits the entry of leukocytes and potentially harmful
substances from the circulation into the central nervous system (CNS). While BBB defects …
substances from the circulation into the central nervous system (CNS). While BBB defects …
[HTML][HTML] Long-lasting blood-brain barrier dysfunction and neuroinflammation after traumatic brain injury
Background Traumatic brain injury (TBI) causes 10–20% of acquired epilepsy, which
typically develops within 2 years post-injury with poorly understood mechanisms. We …
typically develops within 2 years post-injury with poorly understood mechanisms. We …
Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair
Peroxisome proliferator-activated receptor γ (PPARγ) is a widely expressed ligand-
modulated transcription factor that governs the expression of genes involved in …
modulated transcription factor that governs the expression of genes involved in …
Cerebral edema in traumatic brain injury: pathophysiology and prospective therapeutic targets
Traumatic brain injury (TBI) is a complex and heterogeneous disorder with a tremendous
public health burden. It is grossly defined as an alteration in brain function or other evidence …
public health burden. It is grossly defined as an alteration in brain function or other evidence …
Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit
Background Understanding blood-brain barrier responses to inflammatory stimulation (such
as lipopolysaccharide mimicking a systemic infection or a cytokine cocktail that could be the …
as lipopolysaccharide mimicking a systemic infection or a cytokine cocktail that could be the …