Turnitin
降AI改写
早检测系统
早降重系统
Turnitin-UK版
万方检测-期刊版
维普编辑部版
Grammarly检测
Paperpass检测
checkpass检测
PaperYY检测
Targeting the latent reservoir for HIV-1
S Sengupta, RF Siliciano - Immunity, 2018 - cell.com
Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
HIV latency
HIV-1 can establish a state of latent infection at the level of individual T cells. Latently
infected cells are rare in vivo and appear to arise when activated CD4+ T cells, the major …
infected cells are rare in vivo and appear to arise when activated CD4+ T cells, the major …
Proliferation of latently infected CD4+ T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics
A latent reservoir for HIV-1 in resting CD4+ T lymphocytes precludes cure. Mechanisms
underlying reservoir stability are unclear. Recent studies suggest an unexpected degree of …
underlying reservoir stability are unclear. Recent studies suggest an unexpected degree of …
[HTML][HTML] Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure
Antiretroviral therapy fails to cure HIV-1 infection because latent proviruses persist in resting
CD4+ T cells. T cell activation reverses latency, but< 1% of proviruses are induced to …
CD4+ T cells. T cell activation reverses latency, but< 1% of proviruses are induced to …
HIV latency in isolated patient CD4+ T cells may be due to blocks in HIV transcriptional elongation, completion, and splicing
Latently infected CD4+ T cells are the main barrier to complete clearance of HIV infection,
but it is unclear what mechanisms govern latent HIV infection in vivo. To address this …
but it is unclear what mechanisms govern latent HIV infection in vivo. To address this …
Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations
Despite antiretroviral therapy (ART), human immunodeficiency virus (HIV)-1 persists in a
stable latent reservoir,, primarily in resting memory CD4+ T cells,. This reservoir presents a …
stable latent reservoir,, primarily in resting memory CD4+ T cells,. This reservoir presents a …
Ex vivo analysis identifies effective HIV-1 latency–reversing drug combinations
Reversal of HIV-1 latency by small molecules is a potential cure strategy. This approach will
likely require effective drug combinations to achieve high levels of latency reversal. Using …
likely require effective drug combinations to achieve high levels of latency reversal. Using …
Expanded cellular clones carrying replication-competent HIV-1 persist, wax, and wane
The latent reservoir for HIV-1 in resting CD4+ T cells is a major barrier to cure. Several lines
of evidence suggest that the latent reservoir is maintained through cellular proliferation …
of evidence suggest that the latent reservoir is maintained through cellular proliferation …
New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo
HIV-1 persists in a latent reservoir despite antiretroviral therapy (ART),,,,. This reservoir is the
major barrier to HIV-1 eradication,. Current approaches to purging the latent reservoir …
major barrier to HIV-1 eradication,. Current approaches to purging the latent reservoir …
Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies
HIV-1 reservoirs preclude virus eradication in patients receiving highly active antiretroviral
therapy (HAART). The best characterized reservoir is a small, difficult-to-quantify pool of …
therapy (HAART). The best characterized reservoir is a small, difficult-to-quantify pool of …