Precise spatio–temporal control of gene activity is essential for organismal development,
growth, and survival in a changing environment. Decisive steps in gene regulation involve …

The elongation stage of transcription by RNA polymerase II (RNA Pol II) is central to the
regulation of gene expression in response to developmental and environmental cues in …

Summary RNA polymerase II (RNA Pol II) is generally paused at promoter-proximal regions
in most metazoans, and based on in vitro studies, this function has been attributed to the …

Most BRCA1-associated breast tumours are basal-like yet originate from luminal
progenitors. BRCA1 is best known for its functions in double-strand break repair and …

Proper regulation of gene expression is essential for the differentiation, development and
survival of all cells and organisms. Recent work demonstrates that transcription of many …

The remarkable capacity for pluripotency and self-renewal in embryonic stem cells (ESCs)
requires a finely tuned transcriptional circuitry wherein the pathways and genes that initiate …

Promoter-proximal pausing by RNA polymerase II (Pol II) is a well-established mechanism to
control the timing, rate, and possibly the magnitude of transcriptional responses. Recent …

Targeted protein degradation methods offer a unique avenue to assess a protein's function
in a variety of model systems. Recently, these approaches have been applied to mammalian …

DRB sensitivity-inducing factor (DSIF) and negative elongation factor (NELF) were originally
identified as factors responsible for transcriptional inhibition by 5, 6-dichloro-1-beta-d …

The coordinated regulation of transcriptional networks underpins cellular identity and
developmental progression. RNA polymerase II promoter-proximal pausing (Pol II pausing) …