Mitochondrial signal transduction
The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic,
maternally inherited, energy-transforming, biosynthetic, and signaling organelles that …
maternally inherited, energy-transforming, biosynthetic, and signaling organelles that …
Histone acylations and chromatin dynamics: concepts, challenges, and links to metabolism
S Nitsch, L Zorro Shahidian, R Schneider - EMBO reports, 2021 - embopress.org
In eukaryotic cells, DNA is tightly packed with the help of histone proteins into chromatin.
Chromatin architecture can be modified by various post‐translational modifications of …
Chromatin architecture can be modified by various post‐translational modifications of …
Control of histone demethylation by nuclear-localized α-ketoglutarate dehydrogenase
F Huang, X Luo, Y Ou, Z Gao, Q Tang, Z Chu, X Zhu… - Science, 2023 - science.org
Methylations on nucleosomal histones play fundamental roles in regulating eukaryotic
transcription. Jumonji C domain–containing histone demethylases (JMJs) dynamically …
transcription. Jumonji C domain–containing histone demethylases (JMJs) dynamically …
Cardiac metabolism in HFpEF: from fuel to signalling
Heart failure (HF) is marked by distinctive changes in myocardial uptake and utilization of
energy substrates. Among the different types of HF, HF with preserved ejection fraction …
energy substrates. Among the different types of HF, HF with preserved ejection fraction …
Metabolic regulation of the plant epigenome
Y Lu, Q Bu, M Chuan, X Cui, Y Zhao… - The Plant …, 2023 - Wiley Online Library
Chromatin modifications shape the epigenome and are essential for gene expression
reprogramming during plant development and adaptation to the changing environment …
reprogramming during plant development and adaptation to the changing environment …
ACL and HAT1 form a nuclear module to acetylate histone H4K5 and promote cell proliferation
Q Xu, Y Yue, B Liu, Z Chen, X Ma, J Wang… - Nature …, 2023 - nature.com
Acetyl-CoA utilized by histone acetyltransferases (HAT) for chromatin modification is mainly
generated by ATP-citrate lyase (ACL) from glucose sources. How ACL locally establishes …
generated by ATP-citrate lyase (ACL) from glucose sources. How ACL locally establishes …
ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response
LQJ Lim, L Adler, E Hajaj, LR Soria, RBT Perry… - Nature …, 2024 - nature.com
Downregulation of the urea cycle enzyme argininosuccinate synthase (ASS1) in multiple
tumors is associated with a poor prognosis partly because of the metabolic diversion of …
tumors is associated with a poor prognosis partly because of the metabolic diversion of …
Lysine acetylation of histone acetyltransferase adaptor protein ADA2 is a mechanism of metabolic control of chromatin modification in plants
Histone acetylation is a predominant active chromatin mark deposited by histone
acetyltransferases (HATs) that transfer the acetyl group from acetyl coenzyme A (acetyl-CoA) …
acetyltransferases (HATs) that transfer the acetyl group from acetyl coenzyme A (acetyl-CoA) …
Glycolytic flux-signaling controls mouse embryo mesoderm development
How cellular metabolic state impacts cellular programs is a fundamental, unresolved
question. Here, we investigated how glycolytic flux impacts embryonic development, using …
question. Here, we investigated how glycolytic flux impacts embryonic development, using …
ACO2 deficiency increases vulnerability to Parkinson's disease via dysregulating mitochondrial function and histone acetylation-mediated transcription of autophagy …
J Zhu, F Xu, H Lai, H Yuan, XY Li, J Hu, W Li… - Communications …, 2023 - nature.com
Parkinson's disease (PD) is characterized by α-synuclein aggregation in dopaminergic (DA)
neurons, which are sensitive to oxidative stress. Mitochondria aconitase 2 (ACO2) is an …
neurons, which are sensitive to oxidative stress. Mitochondria aconitase 2 (ACO2) is an …