The role of chromatin loop extrusion in antibody diversification
Cohesin mediates chromatin loop formation across the genome by extruding chromatin
between convergently oriented CTCF-binding elements. Recent studies indicate that …
between convergently oriented CTCF-binding elements. Recent studies indicate that …
Genome instability in multiple myeloma: Facts and factors
Simple Summary Multiple myeloma is an incurable blood cancer caused by the malignant
transformation of immunoglobulin-producing plasma cells. The mechanisms leading to the …
transformation of immunoglobulin-producing plasma cells. The mechanisms leading to the …
De novo prediction of human chromosome structures: Epigenetic marking patterns encode genome architecture
Inside the cell nucleus, genomes fold into organized structures that are characteristic of cell
type. Here, we show that this chromatin architecture can be predicted de novo using …
type. Here, we show that this chromatin architecture can be predicted de novo using …
Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire
Variation in the antibody response has been linked to differential outcomes in disease, and
suboptimal vaccine and therapeutic responsiveness, the determinants of which have not …
suboptimal vaccine and therapeutic responsiveness, the determinants of which have not …
Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation
R Vilarrasa-Blasi, P Soler-Vila, N Verdaguer-Dot… - Nature …, 2021 - nature.com
To investigate the three-dimensional (3D) genome architecture across normal B cell
differentiation and in neoplastic cells from different subtypes of chronic lymphocytic leukemia …
differentiation and in neoplastic cells from different subtypes of chronic lymphocytic leukemia …
Contribution of the IGCR1 regulatory element and the 3′Igh CTCF-binding elements to regulation of Igh V(D)J recombination
Immunoglobulin heavy chain variable region exons are assembled in progenitor-B cells,
from VH, D, and JH gene segments located in separate clusters across the Igh locus. RAG …
from VH, D, and JH gene segments located in separate clusters across the Igh locus. RAG …
Transcription-factor-mediated supervision of global genome architecture maintains B cell identity
Recent studies have elucidated cell-lineage-specific three-dimensional genome
organization; however, how such specific architecture is established or maintained is …
organization; however, how such specific architecture is established or maintained is …
Reprogramming the antigen specificity of B cells using genome-editing technologies
We have developed a method to introduce novel paratopes into the human antibody
repertoire by modifying the immunoglobulin (Ig) genes of mature B cells directly using …
repertoire by modifying the immunoglobulin (Ig) genes of mature B cells directly using …
An Igh distal enhancer modulates antigen receptor diversity by determining locus conformation
The mouse Igh locus is organized into a developmentally regulated topologically associated
domain (TAD) that is divided into subTADs. Here we identify a series of distal VH enhancers …
domain (TAD) that is divided into subTADs. Here we identify a series of distal VH enhancers …
Uncovering the statistical physics of 3D chromosomal organization using data-driven modeling
In recent years, much effort has been devoted to understanding the three-dimensional (3D)
organization of the genome and how genomic structure mediates nuclear function. The …
organization of the genome and how genomic structure mediates nuclear function. The …