The human gene catalogue is essentially complete, but we lack an equivalently vetted
inventory of bona fide human enhancers. Hundreds of thousands of candidate enhancers …

Over the last quarter century, more than 532 genes have been put forward as regulatory
targets of retinoic acid. In some cases this control is direct, driven by a liganded heterodimer …

The human genome holds an extraordinary trove of information about human development,
physiology, medicine and evolution. Here we report the results of an international …

The sequence of the mouse genome is a key informational tool for understanding the
contents of the human genome and a key experimental tool for biomedical research. Here …

In the past century, nearly all of the biological sciences have been directly affected by
discoveries and developments in genetics, a fast-evolving subject with important theoretical …

There are 481 segments longer than 200 base pairs (bp) that are absolutely conserved
(100% identity with no insertions or deletions) between orthologous regions of the human …

Comparisons of orthologous genomic DNA sequences can be used to characterize regions
that have been subject to purifying selection and are enriched for functional elements. We …

Gene regulatory networks are the most complex, extensive control systems found in nature.
The interaction between biology and evolution has been the subject of great interest in …

Gene expression is central to the genotype-phenotype relationship in all organisms, and it is
an important component of the genetic basis for evolutionary change in diverse aspects of …

We have identified 242 Anopheles gambiae genes from 18 gene families implicated in
innate immunity and have detected marked diversification relative to Drosophila …