Memory CD8 T cells are an important component of protective immunity against viral
infections, and understanding their development will aid in the design of optimal vaccines …

Clearance of primary infection often leads to the development of highly functional memory T
cells capable of rapid and long-lasting protective immunity. By contrast, chronic infections …

A mathematical model for the CD8+ T-cell response to Human T cell leukemia/lymphoma
virus type I (HTLV-I) infection is investigated in this paper. The proposed model, which …

Chronic viral infections often result in ineffective CD8 T-cell responses due to functional
exhaustion or physical deletion of virus-specific T cells. However, how persisting virus …

Major histocompatibility complex (MHC) class I molecules present peptide ligands on the
cell surface for recognition by appropriate cytotoxic T cells. MHC-bound peptides are critical …

This paper deals with a four dimensional mathematical model for Human T-cell leukemia
virus type-I (HTLV-I) infection that includes delayed CD8+ cytotoxic T-cells (CTLs) immune …

The basis for T cell antigen receptor (TCR) repertoire selection upon repeated antigenic
challenge is unclear. We evaluated the avidity and dissociation kinetics of peptide/major …

Major histocompatibility complex (MHC) class I molecules associate with a variety of peptide
ligands during biosynthesis and present these ligands on the cell surface for recognition by …

Adoptive immunotherapy holds promise as a treatment for cancer and infectious diseases,
but its development has been impeded by the lack of reproducible methods for generating …

T cell responsiveness to an epitope is affected both by its affinity for the presenting MHC
molecule and the affinity of the MHC-peptide complex for TCR. One limitation of cancer …