Machine learning applications in genetics and genomics

MW Libbrecht, WS Noble - Nature Reviews Genetics, 2015 - nature.com
The field of machine learning, which aims to develop computer algorithms that improve with
experience, holds promise to enable computers to assist humans in the analysis of large …

Supervised, unsupervised, and semi-supervised feature selection: a review on gene selection

JC Ang, A Mirzal, H Haron… - IEEE/ACM transactions …, 2015 - ieeexplore.ieee.org
Recently, feature selection and dimensionality reduction have become fundamental tools for
many data mining tasks, especially for processing high-dimensional data such as gene …

Predicting property prices with machine learning algorithms

WKO Ho, BS Tang, SW Wong - Journal of Property Research, 2021 - Taylor & Francis
This study uses three machine learning algorithms including, support vector machine (SVM),
random forest (RF) and gradient boosting machine (GBM) in the appraisal of property prices …

Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers

C Liu, J Zhao, F Tian, L Cai, W Zhang, Q Feng… - Nature biomedical …, 2019 - nature.com
Non-invasive assays for early cancer screening are hampered by challenges in the isolation
and profiling of circulating biomarkers. Here, we show that surface proteins from serum …

A stacking ensemble deep learning approach to cancer type classification based on TCGA data

M Mohammed, H Mwambi, IB Mboya, MK Elbashir… - Scientific reports, 2021 - nature.com
Cancer tumor classification based on morphological characteristics alone has been shown
to have serious limitations. Breast, lung, colorectal, thyroid, and ovarian are the most …

Correlation feature selection based improved-binary particle swarm optimization for gene selection and cancer classification

I Jain, VK Jain, R Jain - Applied Soft Computing, 2018 - Elsevier
DNA microarray technology has emerged as a prospective tool for diagnosis of cancer and
its classification. It provides better insights of many genetic mutations occurring within a cell …

[HTML][HTML] RNA-Seq of tumor-educated platelets enables blood-based pan-cancer, multiclass, and molecular pathway cancer diagnostics

MG Best, N Sol, I Kooi, J Tannous, BA Westerman… - Cancer cell, 2015 - cell.com
Tumor-educated blood platelets (TEPs) are implicated as central players in the systemic and
local responses to tumor growth, thereby altering their RNA profile. We determined the …

Endoplasmic reticulum stress and the hallmarks of cancer

H Urra, E Dufey, T Avril, E Chevet, C Hetz - Trends in cancer, 2016 - cell.com
Tumor cells are often exposed to intrinsic and external factors that alter protein homeostasis,
thus producing endoplasmic reticulum (ER) stress. To cope with this, cells evoke an …

A review of microarray datasets and applied feature selection methods

V Bolón-Canedo, N Sánchez-Marono… - Information …, 2014 - Elsevier
Microarray data classification is a difficult challenge for machine learning researchers due to
its high number of features and the small sample sizes. Feature selection has been soon …

Cancer transcriptome profiling at the juncture of clinical translation

M Cieślik, AM Chinnaiyan - Nature Reviews Genetics, 2018 - nature.com
Methodological breakthroughs over the past four decades have repeatedly revolutionized
transcriptome profiling. Using RNA sequencing (RNA-seq), it has now become possible to …