Sex differences in autism spectrum disorder: diagnostic, neurobiological, and behavioral features

A Napolitano, S Schiavi, P La Rosa… - Frontiers in …, 2022 - frontiersin.org
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder with a
worldwide prevalence of about 1%, characterized by impairments in social interaction …

[HTML][HTML] The neurobiology of social play behaviour: past, present and future

EJM Achterberg, LJMJ Vanderschuren - Neuroscience & Biobehavioral …, 2023 - Elsevier
Social play behaviour is a highly energetic and rewarding activity that is of great importance
for the development of brain and behaviour. Social play is abundant during the juvenile and …

Cannabinoid treatment for autism: a proof-of-concept randomized trial

A Aran, M Harel, H Cassuto, L Polyansky, A Schnapp… - Molecular autism, 2021 - Springer
Background Endocannabinoid dysfunction in animal models of autism spectrum disorder
(ASD) and accumulating, albeit anecdotal, evidence for efficacy in humans motivated this …

A systematic review of the valproic-acid-induced rodent model of autism

D Chaliha, M Albrecht, M Vaccarezza… - Developmental …, 2020 - karger.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by
repetitive behaviours, cognitive rigidity/inflexibility, and social-affective impairment …

Three decades of valproate: a current model for studying autism spectrum disorder

D Zarate-Lopez, AL Torres-Chávez… - Current …, 2024 - benthamdirect.com
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with increased
prevalence and incidence in recent decades. Its etiology remains largely unclear, but it …

[HTML][HTML] A systematic review of cannabidiol trials in neurodevelopmental disorders

NF Parrella, AT Hill, PG Enticott, P Barhoun… - Pharmacology …, 2023 - Elsevier
Cannabis-derived compounds, such as cannabidiol (CBD) and delta-9-trans-
tetrahydrocannabinol (THC), are increasingly prescribed for a range of clinical indications …

Cannabidivarin treatment ameliorates autism-like behaviors and restores hippocampal endocannabinoid system and glia alterations induced by prenatal valproic acid …

E Zamberletti, M Gabaglio… - Frontiers in cellular …, 2019 - frontiersin.org
Autism spectrum disorder (ASD) is a developmental condition whose primary features
include social communication and interaction impairments with restricted or repetitive motor …

Lower circulating endocannabinoid levels in children with autism spectrum disorder

A Aran, M Eylon, M Harel, L Polianski, A Nemirovski… - Molecular autism, 2019 - Springer
Background The endocannabinoid system (ECS) is a major regulator of synaptic plasticity
and neuromodulation. Alterations of the ECS have been demonstrated in several animal …

Prenatal valproate in rodents as a tool to understand the neural underpinnings of social dysfunctions in autism spectrum disorder

AM Tartaglione, S Schiavi, G Calamandrei, V Trezza - Neuropharmacology, 2019 - Elsevier
Impairments in social interaction and verbal and non verbal communication are among the
main features of Autism Spectrum Disorder (ASD). The causes of ASD are still unknown but …

Epigenetics of autism spectrum disorder: Histone deacetylases

CEJ Tseng, CJ McDougle, JM Hooker, NR Zürcher - Biological psychiatry, 2022 - Elsevier
The etiology of autism spectrum disorder (ASD) remains unknown, but gene-environment
interactions, mediated through epigenetic mechanisms, are thought to be a key contributing …