At the dawn of the era of personalized, systems-driven medicine, computational or in silico
modeling and the simulation of disease processes is becoming increasingly important for …

The standard linear-quadratic (LQ) survival model for external beam radiotherapy is
reviewed with particular emphasis on studying how different schedules of radiation …

Glioblastomas (GBMs) are the most common and malignant primary brain tumors and are
aggressively treated with surgery, chemotherapy, and radiotherapy. Despite this treatment …

Cancer development is a stepwise process through which normal somatic cells acquire
mutations which enable them to escape their normal function in the tissue and become self …

Glioblastoma extensively infiltrates the brain; despite surgery and aggressive therapies, the
prognosis is poor. A multidisciplinary approach combining mathematical, clinical and …

In spite of all efforts, patients diagnosed with highly malignant brain tumors (gliomas),
continue to face a grim prognosis. Achieving significant therapeutic advances will also …

A multiscale tumour simulation model employing cell-line-specific biological parameters and
functional information derived from pre-therapy PET/CT imaging data was developed to …

A tumour control probability computational model for fractionated radiotherapy was
developed, with the goal of incorporating the fundamental interplay between hypoxia and …

Glioblastomas are the most aggressive primary brain tumor. Despite treatment with surgery,
radiation and chemotherapy, these tumors remain uncurable and few significant increases …

Background Laparoscopy is widely used in pancreatic surgeries nowadays. The efficient
and correct judgment of the location of the anatomical structures is crucial for a safe …