The advantages and challenges of using endolysins in a clinical setting

E Murray, LA Draper, RP Ross, C Hill - Viruses, 2021 - mdpi.com
Antibiotic-resistant pathogens are increasingly more prevalent and problematic. Traditional
antibiotics are no longer a viable option for dealing with these multidrug-resistant microbes …

The current state of peptide drug discovery: back to the future?

A Henninot, JC Collins, JM Nuss - Journal of medicinal chemistry, 2018 - ACS Publications
Over the past decade, peptide drug discovery has experienced a revival of interest and
scientific momentum, as the pharmaceutical industry has come to appreciate the role that …

Nanocrystals as a master key to deliver hydrophobic drugs via multiple administration routes

MB McGuckin, J Wang, R Ghanma, N Qin… - Journal of controlled …, 2022 - Elsevier
The poor aqueous solubility of many approved drugs and most new chemical entities poses
a challenge to drug delivery scientists working in academic and industrial labs. Despite the …

[HTML][HTML] Recent advances in carrier mediated nose-to-brain delivery of pharmaceutics

V Bourganis, O Kammona, A Alexopoulos… - European journal of …, 2018 - Elsevier
Central nervous system (CNS) disorders (eg, multiple sclerosis, Alzheimer's disease, etc.)
represent a growing public health issue, primarily due to the increased life expectancy and …

[HTML][HTML] Target specific tight junction modulators

J Brunner, S Ragupathy, G Borchard - Advanced drug delivery reviews, 2021 - Elsevier
Intercellular tight junctions represent a formidable barrier against paracellular drug
absorption at epithelia (eg, nasal, intestinal) and the endothelium (eg, blood–brain barrier) …

[HTML][HTML] Treating bacterial infections with bacteriophage-based enzybiotics: in vitro, in vivo and clinical application

KM Danis-Wlodarczyk, DJ Wozniak, ST Abedon - Antibiotics, 2021 - mdpi.com
Over the past few decades, we have witnessed a surge around the world in the emergence
of antibiotic-resistant bacteria. This global health threat arose mainly due to the overuse and …

Nasal route for vaccine and drug delivery: Features and current opportunities

YL Mato - International journal of pharmaceutics, 2019 - Elsevier
Mucosal administration, and specifically nasal route, constitutes an alternative and
promising strategy for drug and vaccine delivery. Mucosal routes have several advantages …

Polyacrylic acid-based drug delivery systems: A comprehensive review on the state-of-art

G Dalei, S Das - Journal of Drug Delivery Science and Technology, 2022 - Elsevier
Polyacrylic acid (PAA)-based drug carrier systems have garnered much significance
towards the delivery of various therapeutic agents via different administration routes for the …

Polymeric nanoparticles for nasal drug delivery to the brain: relevance to Alzheimer's disease

N Rabiee, S Ahmadi, R Afshari, S Khalaji… - Advanced …, 2021 - Wiley Online Library
Currently, Alzheimer's disease (AD) accounts for more than half of all dementia cases.
Although genetics, age, and environmental factors affect the disease, the cause of AD is not …

[HTML][HTML] Innovative drying technologies for biopharmaceuticals

A Sharma, D Khamar, S Cullen, A Hayden… - International Journal of …, 2021 - Elsevier
In the past two decades, biopharmaceuticals have been a breakthrough in improving the
quality of lives of patients with various cancers, autoimmune, genetic disorders etc. With the …