Water as an active constituent in cell biology
P Ball - Chemical reviews, 2008 - ACS Publications
When Szent-Györgyi called water the “matrix of life”, 1 he was echoing an old sentiment.
Paracelsus in the 16th century said that “water was the matrix of the world and of all its …
Paracelsus in the 16th century said that “water was the matrix of the world and of all its …
Cosolvent effects on protein stability
Proteins are marginally stable, and the folding/unfolding equilibrium of proteins in aqueous
solution can easily be altered by the addition of small organic molecules known as …
solution can easily be altered by the addition of small organic molecules known as …
Hydrogels in emerging technologies for type 1 diabetes
Type 1 diabetes therapies that afford tighter glycemic control in a more manageable and
painless manner for patients has remained a central focus of next-generation diabetes …
painless manner for patients has remained a central focus of next-generation diabetes …
Urea as a hydrogen bond producer for fabricating mechanically very strong hydrogels
Y Wu, Y Shi, H Wang - Macromolecules, 2023 - ACS Publications
Hydrogen bonding plays a very important role in the construction and stabilization of natural
and synthetic polymeric materials. Urea is generally considered and used as a hydrogen …
and synthetic polymeric materials. Urea is generally considered and used as a hydrogen …
Urea denaturation by stronger dispersion interactions with proteins than water implies a 2-stage unfolding
L Hua, R Zhou, D Thirumalai… - Proceedings of the …, 2008 - National Acad Sciences
The mechanism of denaturation of proteins by urea is explored by using all-atom
microseconds molecular dynamics simulations of hen lysozyme generated on BlueGene/L …
microseconds molecular dynamics simulations of hen lysozyme generated on BlueGene/L …
Mechanism by which 2, 2, 2-trifluoroethanol/water mixtures stabilize secondary-structure formation in peptides: a molecular dynamics study
D Roccatano, G Colombo… - Proceedings of the …, 2002 - National Acad Sciences
Molecular dynamics simulation techniques have been used to investigate the effect of 2, 2, 2-
trifluoroethanol (TFE) as a cosolvent on the stability of three different secondary structure …
trifluoroethanol (TFE) as a cosolvent on the stability of three different secondary structure …
Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy
The delivery of therapeutic peptides for diabetes therapy is compromised by short half-lives
of drugs with the consequent need for multiple daily injections that reduce patient …
of drugs with the consequent need for multiple daily injections that reduce patient …
Dewetting and hydrophobic interaction in physical and biological systems
Hydrophobicity manifests itself differently on large and small length scales. This review
focuses on large-length-scale hydrophobicity, particularly on dewetting at single …
focuses on large-length-scale hydrophobicity, particularly on dewetting at single …
Interactions between hydrophobic and ionic solutes in aqueous guanidinium chloride and urea solutions: lessons for protein denaturation mechanism
EP O'Brien, RI Dima, B Brooks… - Journal of the American …, 2007 - ACS Publications
In order to clarify the mechanism of denaturant-induced unfolding of proteins we have
calculated the interactions between hydrophobic and ionic species in aqueous guanidinium …
calculated the interactions between hydrophobic and ionic species in aqueous guanidinium …
Urea's action on hydrophobic interactions
For more than a century, urea has been commonly used as an agent for denaturing proteins.
However, the mechanism behind its denaturing power is still not well understood. Here we …
However, the mechanism behind its denaturing power is still not well understood. Here we …