Biological biomarkers of oral cancer

A Radaic, P Kamarajan, A Cho, S Wang… - Periodontology …, 2024 - Wiley Online Library
The oral squamous cell carcinoma (OSCC) 5 year survival rate of 41% has marginally
improved in the last few years, with less than a 1% improvement per year from 2005 to 2017 …

The future of circulating tumor DNA as a biomarker in HPV related oropharyngeal squamous cell carcinoma

CT Haring, SM Dermody, P Yalamanchi, SY Kang… - Oral Oncology, 2022 - Elsevier
Human papillomavirus (HPV) related oropharyngeal squamous cell carcinoma (OPSCC) is
associated with improved outcomes compared to non-virally mediated disease. Clinical …

Association of pretreatment circulating tumor tissue–modified viral HPV DNA with clinicopathologic factors in HPV-positive oropharyngeal cancer

EM Rettig, AA Wang, NA Tran, E Carey… - … –Head & Neck …, 2022 - jamanetwork.com
Importance Circulating tumor tissue–modified viral (TTMV) human papillomavirus (HPV)
DNA is a dynamic, clinically relevant biomarker for HPV-positive oropharyngeal squamous …

Patterns of recurrence in head and neck squamous cell carcinoma to inform personalized surveillance protocols

CT Haring, LA Kana, SM Dermody, C Brummel… - Cancer, 2023 - Wiley Online Library
Background Development of evidence‐based post‐treatment surveillance guidelines in
recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) is limited by …

The current status of cell‐free human papillomavirus DNA as a biomarker in cervical cancer and other HPV‐associated tumors: A review

L Sivars, K Palsdottir… - … Journal of Cancer, 2023 - Wiley Online Library
Tumor cells release fragments of their DNA into the circulation, so called cell‐free tumor
DNA (ctDNA), allowing for analysis of tumor DNA in a simple blood test, that is, liquid biopsy …

Circulating tumor HPV DNA for surveillance of HPV-positive oropharyngeal squamous cell carcinoma: A narrative review

KAL Kuhs, JC Brenner, FC Holsinger… - JAMA oncology, 2023 - jamanetwork.com
Importance Human papillomavirus (HPV)–positive oropharyngeal squamous cell carcinoma
has an overall favorable prognosis, yet a subset of patients will experience devastating …

A Prospective Trial of Biomarker-Guided Surveillance for HPV-Positive Oropharynx Cancer Using Plasma Tumor Tissue–Modified Viral HPV DNA

EM Rettig, JD Schoenfeld, J Miller… - Clinical Cancer …, 2025 - aacrjournals.org
Purpose: Observational studies suggest circulating tumor human papillomavirus (HPV) DNA
may facilitate early detection of recurrent HPV-positive oropharynx cancer. We prospectively …

Circulating human papillomavirus DNA in head and neck squamous cell carcinoma: possible applications and future directions

D Adilbay, S Lele, J Pang, A Asarkar, J Calligas… - Cancers, 2022 - mdpi.com
Simple Summary Circulating human papillomavirus DNA is a promising tool in the
management of HPV-positive oropharyngeal cancer. The potential use of this tool will …

Circulating HPV DNA in HPV-associated cancers

G Lin, J Li - Clinica Chimica Acta, 2023 - Elsevier
Human papillomavirus (HPV) infections are the primary cause of almost all cervical cancers,
anal cancers, and a variable proportion of other anogenital tumors, as well as head and …

Tumor-derived exosomes and the role of liquid biopsy in human papillomavirus oropharyngeal squamous cell carcinoma

MM Allevato, JD Smith, MJ Brenner… - The Cancer …, 2023 - journals.lww.com
The global incidence of human papillomavirus–positive (HPV+) head and neck squamous
cell carcinoma (HNSCC) has surged in recent decades, with HPV+ HNSCC accounting for> …