Regulation of blood–brain barrier integrity by microglia in health and disease: a therapeutic opportunity

PT Ronaldson, TP Davis - Journal of Cerebral Blood Flow & …, 2020 - journals.sagepub.com
The blood–brain barrier (BBB) is a critical regulator of CNS homeostasis. It possesses
physical and biochemical characteristics (ie tight junction protein complexes, transporters) …

Structure, function, and regulation of the blood-brain barrier tight junction in central nervous system disorders

JJ Lochhead, J Yang, PT Ronaldson… - Frontiers in physiology, 2020 - frontiersin.org
The blood-brain barrier (BBB) allows the brain to selectively import nutrients and energy
critical to neuronal function while simultaneously excluding neurotoxic substances from the …

Transporters at CNS barrier sites: obstacles or opportunities for drug delivery?

L Sanchez-Covarrubias, LM Slosky… - Current …, 2014 - ingentaconnect.com
The blood-brain barrier (BBB) and blood-cerebrospinal fluid (BCSF) barriers are critical
determinants of CNS homeostasis. Additionally, the BBB and BCSF barriers are formidable …

Disruption in the blood‐brain barrier: The missing link between brain and body inflammation in bipolar disorder?

JP Patel, BN Frey - Neural plasticity, 2015 - Wiley Online Library
The blood‐brain barrier (BBB) regulates the transport of micro‐and macromolecules
between the peripheral blood and the central nervous system (CNS) in order to maintain …

Blood-brain barrier integrity and glial support: mechanisms that can be targeted for novel therapeutic approaches in stroke

PT Ronaldson, TP Davis - Current pharmaceutical design, 2012 - ingentaconnect.com
The blood-brain barrier (BBB) is a critical regulator of brain homeostasis. Additionally, the
BBB is the most significant obstacle to effective CNS drug delivery. It possesses specific …