Neutrophils are the most abundant circulating leukocytes, being the first line of defence
against bacterial and fungal infections. However, neutrophils also contribute to tissue …

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Nowadays, orthodontic treatment has become increasingly popular. However, the biological
mechanisms of orthodontic tooth movement (OTM) have not been fully elucidated. We were …

Osteoimmunology is an interdisciplinary research field focused on the molecular
understanding of the interplay between the immune and skeletal systems. Although …

Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor
signalling. However, recent reports indicate that SYK also mediates other, unexpectedly …

Bone erosion is a central feature of rheumatoid arthritis and is associated with disease
severity and poor functional outcome. Erosion of periarticular cortical bone, the typical …

Discovery and characterization of the cytokine receptor-cytokine-decoy receptor triad formed
by receptor activator of nuclear factor kappa-B ligand (RANKL)–receptor activator of NF-κB …

The immune and skeletal systems share a variety of molecules, including cytokines,
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …

Osteoclasts are multinucleated cells of monocyte/macrophage origin that degrade bone
matrix. The differentiation of osteoclasts is dependent on a tumor necrosis factor (TNF) family …

Bone is a tissue undergoing continuous building and degradation. This remodelling is a
tightly regulated process that can be disturbed by many factors, particularly hormonal …