Importance Primary care clinicians find managing chronic pain challenging. Evidence of
long-term efficacy of opioids for chronic pain is limited. Opioid use is associated with serious …

Objective To investigate how consensus is operationalized in Delphi studies and to explore
the role of consensus in determining the results of these studies. Study Design and Settings …

Since publication of the European League Against Rheumatism (EULAR) recommendations
for management of hand osteoarthritis (OA) in 2007 new evidence has emerged. The aim …

Pain is the predominant symptom for people with inflammatory arthritis (IA) and osteoarthritis
(OA) mandating the development of evidence-based recommendations for the health …

Objectives This review examines the pharmacokinetics, modes of action and therapeutic
properties of the anti-malarial drugs, hydroxychloroquine (HCQ) and chloroquine (CQ), in …

Objective To investigate the efficacy and safety of dietary supplements for patients with
osteoarthritis. Design An intervention systematic review with random effects meta-analysis …

Purpose Although a number of osteoarthritis (OA) management guidelines exist, uptake has
been suboptimal. Our aim was to review and critically evaluate existing OA management …

Abstract Objective To update the American College of Rheumatology (ACR) 2000
recommendations for hip and knee osteoarthritis (OA) and develop new recommendations …

Osteoarthritis is thought to be the most prevalent chronic joint disease. The incidence of
osteoarthritis is rising because of the ageing population and the epidemic of obesity. Pain …

OBJECTIVE: To understand the differences in prevalence and incidence estimates of
osteoarthritis (OA), according to case definition, in knee, hip and hand joints. METHOD: A …