Decoding post-translational modification crosstalk with proteomics
Post-translational modification (PTM) of proteins allows cells to regulate protein functions,
transduce signals and respond to perturbations. PTMs expand protein functionality and …
transduce signals and respond to perturbations. PTMs expand protein functionality and …
Homing in: mechanisms of substrate targeting by protein kinases
Protein phosphorylation is the most common reversible post-translational modification in
eukaryotes. Humans have over 500 protein kinases, of which more than a dozen are …
eukaryotes. Humans have over 500 protein kinases, of which more than a dozen are …
The functional landscape of the human phosphoproteome
Protein phosphorylation is a key post-translational modification regulating protein function in
almost all cellular processes. Although tens of thousands of phosphorylation sites have …
almost all cellular processes. Although tens of thousands of phosphorylation sites have …
In‐depth and 3‐dimensional exploration of the budding yeast phosphoproteome
Phosphorylation is one of the most dynamic and widespread post‐translational
modifications regulating virtually every aspect of eukaryotic cell biology. Here, we assemble …
modifications regulating virtually every aspect of eukaryotic cell biology. Here, we assemble …
Evolution of resilience in protein interactomes across the tree of life
Phenotype robustness to environmental fluctuations is a common biological phenomenon.
Although most phenotypes involve multiple proteins that interact with each other, the basic …
Although most phenotypes involve multiple proteins that interact with each other, the basic …
Finding the ΔΔG spot: Are predictors of binding affinity changes upon mutations in protein–protein interactions ready for it?
Predicting the structure and thermodynamics of protein–protein interactions (PPIs) are key to
a proper understanding and modulation of their function. Since experimental methods might …
a proper understanding and modulation of their function. Since experimental methods might …
High-throughput functional characterization of protein phosphorylation sites in yeast
Phosphorylation is a critical post-translational modification involved in the regulation of
almost all cellular processes. However, fewer than 5% of thousands of recently discovered …
almost all cellular processes. However, fewer than 5% of thousands of recently discovered …
The regulatory landscape of the yeast phosphoproteome
The cellular ability to react to environmental fluctuations depends on signaling networks that
are controlled by the dynamic activities of kinases and phosphatases. Here, to gain insight …
are controlled by the dynamic activities of kinases and phosphatases. Here, to gain insight …
The evolution of post-translational modifications
D Bradley - Current Opinion in Genetics & Development, 2022 - Elsevier
Post-translational modifications (PTMs) are chemical modifications that can regulate the
activity and function of proteins. From an evolutionary perspective, they also represent a fast …
activity and function of proteins. From an evolutionary perspective, they also represent a fast …
Map** protein states and interactions across the tree of life with co-fractionation mass spectrometry
We present CFdb, a harmonized resource of interaction proteomics data from 411 co-
fractionation mass spectrometry (CF-MS) datasets spanning 21,703 fractions. Meta-analysis …
fractionation mass spectrometry (CF-MS) datasets spanning 21,703 fractions. Meta-analysis …