[HTML][HTML] Metabolomic Hallmarks of Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease
From a detailed review of 90 experimental and clinical metabolomic investigations of obesity
and metabolic dysfunction-associated steatotic liver disease (MASLD), we have developed …
and metabolic dysfunction-associated steatotic liver disease (MASLD), we have developed …
The gut microbiota–a vehicle for the prevention and treatment of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) arises principally against a background of cirrhosis and
these two diseases are responsible globally for over 2 million deaths a year. There are few …
these two diseases are responsible globally for over 2 million deaths a year. There are few …
Consumption of grapes modulates gene expression, reduces non-alcoholic fatty liver disease, and extends longevity in female C57BL/6J mice provided with a high-fat …
A key objective of this study was to explore the potential of dietary grape consumption to
modulate adverse effects caused by a high-fat (western-pattern) diet. Female C57BL/6J …
modulate adverse effects caused by a high-fat (western-pattern) diet. Female C57BL/6J …
Metabolic Hijacking of Hexose Metabolism to Ascorbate Synthesis Is the Unifying Biochemical Basis of Murine Liver Fibrosis
We wished to understand the metabolic reprogramming underlying liver fibrosis progression
in mice. Administration to male C57BL/6J mice of the hepatotoxins carbon tetrachloride …
in mice. Administration to male C57BL/6J mice of the hepatotoxins carbon tetrachloride …
Influence of grape consumption on the human microbiome
Over the years, a substantial body of information has accumulated suggesting dietary
consumption of grapes may have a positive influence on human health. Here, we investigate …
consumption of grapes may have a positive influence on human health. Here, we investigate …
[HTML][HTML] Short-term grape consumption diminishes UV-induced skin erythema
Over three million Americans are affected by skin cancer each year, largely as a result of
exposure to sunlight. The purpose of this study was to determine the potential of grape …
exposure to sunlight. The purpose of this study was to determine the potential of grape …
[HTML][HTML] New metabolic insights into the mechanism of ifosfamide encephalopathy
D Beyoğlu, P Hamberg, NS IJzerman… - Biomedicine & …, 2025 - Elsevier
Ifosfamide causes neurotoxicity, including sometimes fatal encephalopathy, in a small
number of patients. Why and how this occurs is not fully understood. It is generally believed …
number of patients. Why and how this occurs is not fully understood. It is generally believed …
Multi-Organ Nutrigenomic Effects of Dietary Grapes in a Mouse Model
As a whole food, the potential health benefits of table grapes have been widely studied.
Some individual constituents have garnered great attention, particularly resveratrol, but …
Some individual constituents have garnered great attention, particularly resveratrol, but …
[HTML][HTML] Long-Term Dietary Consumption of Grapes Affects Kidney Health in C57BL/6J Mice
A Dave, EJ Park, P Kofsky, A Dufresne, S Chakraborty… - Nutrients, 2024 - mdpi.com
Starting at 4 weeks of age, male and female C57BL/6J mice were provided with a semi-
synthetic diet for a period of one year and then continued on the semi-synthetic diet with or …
synthetic diet for a period of one year and then continued on the semi-synthetic diet with or …
Hepatitis C Virus Infection Upregulates Plasma Phosphosphingolipids and Endocannabinoids and Downregulates Lysophosphoinositols
D Beyoğlu, S Schwalm, N Semmo, A Huwiler… - International journal of …, 2023 - mdpi.com
A mass spectrometry-based lipidomic investigation of 30 patients with chronic hepatitis C
virus (HCV) infection and 30 age-and sex-matched healthy blood donor controls was …
virus (HCV) infection and 30 age-and sex-matched healthy blood donor controls was …