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A potential revolution in cancer treatment: A topical review of FLASH radiotherapy
FLASH radiotherapy (RT) is a novel technique in which the ultrahigh dose rate (UHDR)(≥
40 Gy/s) is delivered to the entire treatment volume. Recent outcomes of in vivo studies …
40 Gy/s) is delivered to the entire treatment volume. Recent outcomes of in vivo studies …
Mechanisms of action in FLASH radiotherapy: A comprehensive review of physicochemical and biological processes on cancerous and normal cells
JCL Chow, HE Ruda - Cells, 2024 - mdpi.com
The advent of FLASH radiotherapy (FLASH-RT) has brought forth a paradigm shift in cancer
treatment, showcasing remarkable normal cell sparing effects with ultra-high dose rates (> …
treatment, showcasing remarkable normal cell sparing effects with ultra-high dose rates (> …
FLASH with carbon ions: Tumor control, normal tissue sparing, and distal metastasis in a mouse osteosarcoma model
W Tinganelli, U Weber, A Puspitasari… - Radiotherapy and …, 2022 - Elsevier
Background and purpose The FLASH effect is a potential breakthrough in radiotherapy
because ultra-high dose-rate irradiation can substantially widen the therapeutic window …
because ultra-high dose-rate irradiation can substantially widen the therapeutic window …
FLASH radiotherapy with carbon ion beams
FLASH radiotherapy is considered a new potential breakthrough in cancer treatment. Ultra‐
high dose rates (> 40 Gy/s) have been shown to reduce toxicity in the normal tissue without …
high dose rates (> 40 Gy/s) have been shown to reduce toxicity in the normal tissue without …
[HTML][HTML] May oxygen depletion explain the FLASH effect? A chemical track structure analysis
Background and purpose Recent observations in animal models show that ultra-high dose
rate (“FLASH”) radiation treatment significantly reduces normal tissue toxicity maintaining an …
rate (“FLASH”) radiation treatment significantly reduces normal tissue toxicity maintaining an …
A roadmap to clinical trials for FLASH
While FLASH radiation therapy is inspiring enthusiasm to transform the field, it is neither new
nor well understood with respect to the radiobiological mechanisms. As FLASH clinical trials …
nor well understood with respect to the radiobiological mechanisms. As FLASH clinical trials …
A mechanistic DNA repair and survival model (Medras): applications to intrinsic radiosensitivity, relative biological effectiveness and dose-rate
Variations in the intrinsic radiosensitivity of different cells to ionizing radiation is now widely
believed to be a significant driver in differences in response to radiotherapy. While the …
believed to be a significant driver in differences in response to radiotherapy. While the …
[HTML][HTML] Quantifying the DNA-damaging effects of FLASH irradiation with plasmid DNA
Purpose To investigate a plasmid DNA nicking assay approach for isolating and quantifying
the DNA-damaging effects of ultrahigh-dose-rate (ie, FLASH) irradiation relative to …
the DNA-damaging effects of ultrahigh-dose-rate (ie, FLASH) irradiation relative to …
[HTML][HTML] Particle beam radiobiology status and challenges: a PTCOG radiobiology subcommittee report
Particle Therapy (PT) represents a significant advancement in cancer treatment, precisely
targeting tumor cells while sparing surrounding healthy tissues thanks to the unique depth …
targeting tumor cells while sparing surrounding healthy tissues thanks to the unique depth …
Development of ultra-high dose-rate (FLASH) particle therapy
Research efforts in FLASH radiotherapy (FLASH-RT) have increased at an accelerated pace
recently. FLASH-RT involves ultra-high dose rates and has been shown to reduce toxicity to …
recently. FLASH-RT involves ultra-high dose rates and has been shown to reduce toxicity to …