Mitophagy is an evolutionarily conserved cellular process to remove dysfunctional or
superfluous mitochondria, thus fine-tuning mitochondrial number and preserving energy …

The maintenance of a healthy and functional mitochondrial network is critical during
development as well as throughout life in the response to physiological adaptations and …

Mutations in the protein kinase PINK1 lead to defects in mitophagy and cause autosomal
recessive early onset Parkinson's disease,. PINK1 has many unique features that enable it …

Mitochondria produce energy in the form of ATP via oxidative phosphorylation. As defects in
oxidative phosphorylation can generate harmful reactive oxygen species, it is important that …

Mutations in the E3 ubiquitin ligase parkin (PARK2, also known as PRKN) and the protein
kinase PINK1 (also known as PARK6) are linked to autosomal-recessive juvenile …

Despite their importance as signaling hubs, the function of mitochondria-ER contact sites in
mitochondrial quality control pathways remains unexplored. Here we describe a mechanism …

E3 ligases are typically classified by hallmark domains such as RING and RBR, which are
thought to specify unique catalytic mechanisms of ubiquitin transfer to recruited substrates …

Current models of selective autophagy dictate that autophagy receptors, including
Optineurin and NDP52, link cargo to autophagosomal membranes. This is thought to occur …

Mutations in E3 ubiquitin ligase Parkin have been linked to familial Parkinson's disease.
Accumulating evidence suggests that Parkin is a tumor suppressor, but the underlying …

Mutations in the PTEN-induced kinase 1 (PINK1) and Parkin RBR E3 ubiquitin-protein
ligase (PARKIN) genes are associated with familial forms of Parkinson's disease (PD) …