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Alcohol-associated liver disease
Alcohol-associated liver disease (ALD) is a major cause of chronic liver disease worldwide,
and comprises a spectrum of several different disorders, including simple steatosis …
and comprises a spectrum of several different disorders, including simple steatosis …
Molecular and cellular mechanisms of liver fibrosis and its regression
T Kisseleva, D Brenner - Nature reviews Gastroenterology & hepatology, 2021 - nature.com
Chronic liver injury leads to liver inflammation and fibrosis, through which activated
myofibroblasts in the liver secrete extracellular matrix proteins that generate the fibrous scar …
myofibroblasts in the liver secrete extracellular matrix proteins that generate the fibrous scar …
Hidradenitis suppurativa
Hidradenitis suppurativa is a chronic inflammatory disease characterised by painful, deep-
seated nodules, abscesses, and draining tunnels in the skin of axillary, inguinal, genitoanal …
seated nodules, abscesses, and draining tunnels in the skin of axillary, inguinal, genitoanal …
IL-10 family cytokines IL-10 and IL-22: from basic science to clinical translation
W Ouyang, A O'Garra - Immunity, 2019 - cell.com
Cytokines are among the most important effector and messenger molecules in the immune
system. They profoundly participate in immune responses during infection and inflammation …
system. They profoundly participate in immune responses during infection and inflammation …
Mechanisms of liver fibrosis and its role in liver cancer
Hepatic fibrogenesis is a pathophysiological outcome of chronic liver injury hallmarked by
excessive accumulation of extracellular matrix proteins. Fibrosis is a dynamic process that …
excessive accumulation of extracellular matrix proteins. Fibrosis is a dynamic process that …
The roles of critical pro‐inflammatory cytokines in the drive of cytokine storm during SARS‐CoV‐2 infection
In patients with severe COVID‐19, acute respiratory distress syndrome (ARDS), multiple
organ dysfunction syndrome (MODS), and even mortality can result from cytokine storm …
organ dysfunction syndrome (MODS), and even mortality can result from cytokine storm …
The role of cytokines and chemokines in severe acute respiratory syndrome coronavirus 2 infections
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in countless
infections and caused millions of deaths since its emergence in 2019. Coronavirus disease …
infections and caused millions of deaths since its emergence in 2019. Coronavirus disease …
Role of Th22 cells in the pathogenesis of autoimmune diseases
Upon antigenic stimulation, naïve CD4+ T cells differentiate into different subsets and
secrete various cytokines to exert biological effects. Th22 cells, a newly identified CD4+ T …
secrete various cytokines to exert biological effects. Th22 cells, a newly identified CD4+ T …
Reparative inflammation takes charge of tissue regeneration
Inflammation underlies many chronic and degenerative diseases, but it also mitigates
infections, clears damaged cells and initiates tissue repair. Many of the mechanisms that link …
infections, clears damaged cells and initiates tissue repair. Many of the mechanisms that link …
Liver fibrosis: Pathophysiology and clinical implications
J Berumen, J Baglieri, T Kisseleva… - WIREs mechanisms of …, 2021 - Wiley Online Library
Liver fibrosis is a clinically significant finding that has major impacts on patient morbidity and
mortality. The mechanism of fibrosis involves many different cellular pathways, but the major …
mortality. The mechanism of fibrosis involves many different cellular pathways, but the major …