Alcohol-associated liver disease

B Mackowiak, Y Fu, L Maccioni, B Gao - The Journal of clinical …, 2024 - jci.org
Alcohol-associated liver disease (ALD) is a major cause of chronic liver disease worldwide,
and comprises a spectrum of several different disorders, including simple steatosis …

Molecular and cellular mechanisms of liver fibrosis and its regression

T Kisseleva, D Brenner - Nature reviews Gastroenterology & hepatology, 2021 - nature.com
Chronic liver injury leads to liver inflammation and fibrosis, through which activated
myofibroblasts in the liver secrete extracellular matrix proteins that generate the fibrous scar …

Hidradenitis suppurativa

R Sabat, A Alavi, K Wolk, X Wortsman, B McGrath… - The Lancet, 2025 - thelancet.com
Hidradenitis suppurativa is a chronic inflammatory disease characterised by painful, deep-
seated nodules, abscesses, and draining tunnels in the skin of axillary, inguinal, genitoanal …

IL-10 family cytokines IL-10 and IL-22: from basic science to clinical translation

W Ouyang, A O'Garra - Immunity, 2019 - cell.com
Cytokines are among the most important effector and messenger molecules in the immune
system. They profoundly participate in immune responses during infection and inflammation …

Mechanisms of liver fibrosis and its role in liver cancer

D Dhar, J Baglieri, T Kisseleva… - … Biology and Medicine, 2020 - journals.sagepub.com
Hepatic fibrogenesis is a pathophysiological outcome of chronic liver injury hallmarked by
excessive accumulation of extracellular matrix proteins. Fibrosis is a dynamic process that …

The roles of critical pro‐inflammatory cytokines in the drive of cytokine storm during SARS‐CoV‐2 infection

MS Qudus, M Tian, S Sirajuddin, S Liu… - Journal of Medical …, 2023 - Wiley Online Library
In patients with severe COVID‐19, acute respiratory distress syndrome (ARDS), multiple
organ dysfunction syndrome (MODS), and even mortality can result from cytokine storm …

The role of cytokines and chemokines in severe acute respiratory syndrome coronavirus 2 infections

RJ Hsu, WC Yu, GR Peng, CH Ye, SY Hu… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in countless
infections and caused millions of deaths since its emergence in 2019. Coronavirus disease …

Role of Th22 cells in the pathogenesis of autoimmune diseases

Q Jiang, G Yang, F **ao, J **e, S Wang, L Lu… - Frontiers in …, 2021 - frontiersin.org
Upon antigenic stimulation, naïve CD4+ T cells differentiate into different subsets and
secrete various cytokines to exert biological effects. Th22 cells, a newly identified CD4+ T …

Reparative inflammation takes charge of tissue regeneration

M Karin, H Clevers - Nature, 2016 - nature.com
Inflammation underlies many chronic and degenerative diseases, but it also mitigates
infections, clears damaged cells and initiates tissue repair. Many of the mechanisms that link …

Liver fibrosis: Pathophysiology and clinical implications

J Berumen, J Baglieri, T Kisseleva… - WIREs mechanisms of …, 2021 - Wiley Online Library
Liver fibrosis is a clinically significant finding that has major impacts on patient morbidity and
mortality. The mechanism of fibrosis involves many different cellular pathways, but the major …