The cell cycle is the series of events that take place in a cell, which drives it to divide and
produce two new daughter cells. The typical cell cycle in eukaryotes is composed of the …

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …

The ErbB receptor family, also known as the EGF receptor family or type I receptor family,
includes the epidermal growth factor (EGF) receptor (EGFR) or ErbB1/Her1, ErbB2/Her2 …

Once engaged by soluble or matrix-anchored ligands, cell surface proteins are commonly
sorted to lysosomal degradation through several endocytic pathways. Defective vesicular …

The internalization of various cargo proteins and lipids from the mammalian cell surface
occurs through the clathrin and lipid-raft endocytic pathways. Protein–lipid and protein …

Multiple growth-and differentiation-inducing polypeptide factors bind to and activate
transmembrane receptors tyrosine kinases (RTKs), to instigate a plethora of biochemical …

Our understanding of endocytosis has evolved remarkably in little more than a decade. This
is the result not only of advances in our knowledge of its molecular and biological workings …

Receptor endocytosis is a fundamental step in controlling the magnitude, duration, and
nature of cell signaling events. Confluent endothelial cells are contact inhibited in their …

Recent studies indicate that endocytic organelles can play a more active role in signal
propagation and amplification than was recognised before. By deciphering the interplay …

Protein tyrosine kinases (PTKs) coordinate a broad spectrum of cellular responses to
extracellular stimuli and cell–cell interactions during development, tissue homeostasis, and …