Understanding bacteriophage tail fiber interaction with host surface receptor: the key “blueprint” for reprogramming phage host range
Bacteriophages (phages), as natural antibacterial agents, are being rediscovered because
of the growing threat of multi-and pan-drug-resistant bacterial pathogens globally. However …
of the growing threat of multi-and pan-drug-resistant bacterial pathogens globally. However …
Current clinical landscape and global potential of bacteriophage therapy
NM Hitchcock, D Devequi Gomes Nunes, J Shiach… - Viruses, 2023 - mdpi.com
In response to the global spread of antimicrobial resistance, there is an increased demand
for novel and innovative antimicrobials. Bacteriophages have been known for their potential …
for novel and innovative antimicrobials. Bacteriophages have been known for their potential …
iPHoP: An integrated machine learning framework to maximize host prediction for metagenome-derived viruses of archaea and bacteria
The extraordinary diversity of viruses infecting bacteria and archaea is now primarily studied
through metagenomics. While metagenomes enable high-throughput exploration of the viral …
through metagenomics. While metagenomes enable high-throughput exploration of the viral …
Prediction of strain level phage–host interactions across the Escherichia genus using only genomic information
Predicting bacteriophage infection of specific bacterial strains promises advancements in
phage therapy and microbial ecology. Whether the dynamics of well-established phage …
phage therapy and microbial ecology. Whether the dynamics of well-established phage …
Going viral: virus-based biological control agents for plant protection
The most economically important biotic stresses in crop production are caused by fungi,
oomycetes, insects, viruses, and bacteria. Often chemical control is still the most commonly …
oomycetes, insects, viruses, and bacteria. Often chemical control is still the most commonly …
[HTML][HTML] A perfect fit: Bacteriophage receptor-binding proteins for diagnostic and therapeutic applications
Bacteriophages are the most abundant biological entity on earth, acting as the predators
and evolutionary drivers of bacteria. Owing to their inherent ability to specifically infect and …
and evolutionary drivers of bacteria. Owing to their inherent ability to specifically infect and …
Global overview and major challenges of host prediction methods for uncultivated phages
Highlights•Global phage diversity is now primarily explored through cultivation-independent
metagenomics.•Metagenome-derived phages are typically linked to their host (s) via in silico …
metagenomics.•Metagenome-derived phages are typically linked to their host (s) via in silico …
Bacteriophage-based biosensors for detection of pathogenic microbes in wastewater
KB Shivaram, P Bhatt, MS Verma, K Clase… - Science of The Total …, 2023 - Elsevier
Wastewater is discarded from several sources, including industry, livestock, fertilizer
application, and municipal waste. If the disposed of wastewater has not been treated and …
application, and municipal waste. If the disposed of wastewater has not been treated and …
[HTML][HTML] Microbiome-phage interactions in inflammatory bowel disease
S Federici, D Kviatcovsky, R Valdés-Mas… - Clinical microbiology and …, 2023 - Elsevier
Background Inflammatory bowel disease (IBD) constitutes a group of auto-inflammatory
disorders that impact the gastrointestinal tract and other systemic organs. The gut …
disorders that impact the gastrointestinal tract and other systemic organs. The gut …
Genetic determinants of host tropism in Klebsiella phages
B Beamud, N García-González, M Gómez-Ortega… - Cell reports, 2023 - cell.com
Bacteriophages play key roles in bacterial ecology and evolution and are potential
antimicrobials. However, the determinants of phage-host specificity remain elusive. Here, we …
antimicrobials. However, the determinants of phage-host specificity remain elusive. Here, we …