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Cellular origins of dsRNA, their recognition and consequences
Double-stranded RNA (dsRNA) is associated with most viral infections—it either constitutes
the viral genome (in the case of dsRNA viruses) or is generated in host cells during viral …
the viral genome (in the case of dsRNA viruses) or is generated in host cells during viral …
Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis
Cancers arise through the accumulation of genetic and epigenetic alterations that enable
cells to evade telomere-based proliferative barriers and achieve immortality. One such …
cells to evade telomere-based proliferative barriers and achieve immortality. One such …
The molecular mechanism of RIG‐I activation and signaling
RIG‐I is our first line of defense against RNA viruses, serving as a pattern recognition
receptor that identifies molecular features common among dsRNA and ssRNA viral …
receptor that identifies molecular features common among dsRNA and ssRNA viral …
Comparative structure and function analysis of the RIG-I-like receptors: RIG-I and MDA5
RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated
protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of …
protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of …
Double-stranded RNA sensors and modulators in innate immunity
S Hur - Annual review of immunology, 2019 - annualreviews.org
Detection of double-stranded RNAs (dsRNAs) is a central mechanism of innate immune
defense in many organisms. We here discuss several families of dsRNA-binding proteins …
defense in many organisms. We here discuss several families of dsRNA-binding proteins …
SARS-CoV-2 membrane protein inhibits type I interferon production through ubiquitin-mediated degradation of TBK1
L Sui, Y Zhao, W Wang, P Wu, Z Wang, Y Yu… - Frontiers in …, 2021 - frontiersin.org
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative
pathogen of current COVID-19 pandemic, and insufficient production of type I interferon (IFN …
pathogen of current COVID-19 pandemic, and insufficient production of type I interferon (IFN …
Physiological functions of RIG-I-like receptors
RIG-I-like receptors (RLRs) are crucial for pathogen detection and triggering immune
responses and have immense physiological importance. In this review, we first summarize …
responses and have immense physiological importance. In this review, we first summarize …
Self-recognition of an inducible host lncRNA by RIG-I feedback restricts innate immune response
M Jiang, S Zhang, Z Yang, H Lin, J Zhu, L Liu, W Wang… - Cell, 2018 - cell.com
The innate RNA sensor RIG-I is critical in the initiation of antiviral type I interferons (IFNs)
production upon recognition of" non-self" viral RNAs. Here, we identify a host-derived, IFN …
production upon recognition of" non-self" viral RNAs. Here, we identify a host-derived, IFN …
Detection of microbial infections through innate immune sensing of nucleic acids
Microbial infections are recognized by the innate immune system through germline-encoded
pattern recognition receptors (PRRs). As most microbial pathogens contain DNA and/or …
pattern recognition receptors (PRRs). As most microbial pathogens contain DNA and/or …