Metabolic engineering of Escherichia coli: a sustainable industrial platform for bio-based chemical production

X Chen, L Zhou, K Tian, A Kumar, S Singh… - Biotechnology …, 2013 - Elsevier
In order to decrease carbon emissions and negative environmental impacts of various
pollutants, more bulk and/or fine chemicals are produced by bioprocesses, replacing the …

Sustainable production of natural phenolics for functional food applications

R Mark, X Lyu, JJL Lee, R Parra-Saldívar… - Journal of Functional …, 2019 - Elsevier
Phenolics are a class of plant-derived natural secondary metabolites with good anticancer,
anti-inflammatory, antimicrobial and antioxidant activities. In addition to being natural health …

Cellular factories for coenzyme Q10 production

SQE Lee, TS Tan, M Kawamukai, ES Chen - Microbial cell factories, 2017 - Springer
Abstract Coenzyme Q 10 (CoQ 10), a benzoquinone present in most organisms, plays an
important role in the electron-transport chain, and its deficiency is associated with various …

Engineering complex phenotypes in industrial strains

R Patnaik - Biotechnology Progress, 2008 - Wiley Online Library
The global demand is rising for greener manufacturing processes that are cost‐competitive
and available in a timely manner. This has led to the development of a series of new tools …

Biosynthesis and bioproduction of coenzyme Q10 by yeasts and other organisms

M Kawamukai - Biotechnology and applied biochemistry, 2009 - Wiley Online Library
CoQ (coenzyme Q), an isoprenylated benzoquinone, is a well‐known component of the
electron‐transfer system in eukaryotes. The main role of CoQ is to transfer electrons from …

Biotechnological production and applications of coenzyme Q10

JH Choi, YW Ryu, JH Seo - Applied microbiology and biotechnology, 2005 - Springer
Coenzyme Q 10 is widely used as an essential component of ATP generation in the
oxidative phosphorylation process and as an antioxidant preventing lipid peroxidation and …

Current prospects for the production of coenzyme Q10 in microbes

CP Cluis, AM Burja, VJJ Martin - Trends in biotechnology, 2007 - cell.com
Coenzyme Q or ubiquinone (UQ) is a naturally occurring coenzyme formed from the
conjugation of a benzoquinone ring and an isoprenoid chain of varying length. UQ-10, the …

Production of coenzyme Q10 by purple non-sulfur bacteria: current development and future prospect

S He, H Lu, G Zhang, Z Ren - Journal of Cleaner Production, 2021 - Elsevier
Abstract Coenzyme Q10 (CoQ10) is extensively used in the fields of medicine, cosmetics,
food, and health care due to its function as an adenosine triphosphate (ATP) synthesis …

Current state of coenzyme Q10 production and its applications

M Jeya, HJ Moon, JL Lee, IW Kim, JK Lee - Applied microbiology and …, 2010 - Springer
Abstract Coenzyme Q 10 (CoQ 10), an obligatory cofactor in the aerobic respiratory electron
transfer for energy generation, is formed from the conjugation of a benzoquinone ring with a …

Coenzyme Q10 production in recombinant Escherichia coli strains engineered with a heterologous decaprenyl diphosphate synthase gene and foreign mevalonate …

HS Zahiri, SH Yoon, JD Keasling, SH Lee, SW Kim… - Metabolic …, 2006 - Elsevier
In the present work, Escherichia coli DH5α was metabolically engineered for CoQ10
production by the introduction of decaprenyl diphosphate synthase gene (ddsA) from …