Boolean network models are one of the simplest models to study complex dynamic behavior
in biological systems. They can be applied to unravel the mechanisms regulating the …

In order to understand the functioning of organisms on the molecular level, we need to know
which genes are expressed, when and where in the organism, and to which extent. The …

Motivation: Our goal is to construct a model for genetic regulatory networks such that the
model class:(i) incorporates rule-based dependencies between genes;(ii) allows the …

The major challenge in biology today is biocomplexity: the need to explain how cell and
tissue behaviors emerge from collective interactions within complex molecular networks …

There has been considerable progress in the systemic treatment of cancer because of the
rapid development and clinical application of molecular targeted agents. Although patients …

Abstract motivation: Advances in molecular biological, analytical and computational
technologies are enabling us to systematically investigate the complex molecular processes …

Endometriosis is a gynecological disorder among reproductive-aged women. Recent
epidemiological investigations suggest endometriosis increases the risk of endometrial …

Mathematical and computational modeling of genetic regulatory networks promises to
uncover the fundamental principles governing biological systems in an integrative and …

Development of characteristic tissue patterns requires that individual cells be switched
locally between different phenotypes or “fates;” while one cell may proliferate, its neighbors …

The cellular adhesion and motility have direct implications in the tumoral-metastatic cells
development or in the tissue engineering mechanisms for instance. Our work aims at …