Mitochondria are key to energy conversion in virtually all eukaryotes. Intriguingly, despite
billions of years of evolution inside the eukaryote, mitochondria have retained their own …

The Mother's Curse hypothesis posits that mothers curse their sons with harmful
mitochondria, because maternal mitochondrial inheritance makes selection blind to …

How common is balancing selection, and what fraction of phenotypic variance is attributable
to balanced polymorphisms? Despite decades of research, answers to these questions …

Mitochondria underpin energy conversion in eukaryotes. Their small genomes have been
the subject of increasing attention, and there is evidence that mitochondrial genetic variation …

Antagonistic selection—where alleles at a locus have opposing effects on male and female
fitness (“sexual antagonism”) or between components of fitness (“antagonistic pleiotropy”) …

Background Disorders of the mitochondrial respiratory chain are heterogeneous in their
symptoms and underlying genetics. Simple links between candidate mutations and …

Genetic variation in cytoplasmic genomes (ie the mitochondrial genome in animals, and the
combined mitochondrial and chloroplast genomes in plants) was traditionally assumed to …

Females and males may face different selection pressures. Accordingly, alleles that confer a
benefit for one sex often incur a cost for the other. Classic evolutionary theory holds that the …

According to evolutionary theory, mitochondria could be poisoned gifts that mothers transmit
to their sons. This is because mutations harmful to males are expected to accumulate in the …

Evolutionary theory proposes that maternal inheritance of mitochondria will facilitate the
accumulation of mitochondrial DNA (mtDNA) mutations that are harmful to males but benign …