Cholesterol and COVID-19—therapeutic opportunities at the host/virus interface during cell entry

T Grewal, MKL Nguyen, C Buechler - Life Science Alliance, 2024 - life-science-alliance.org
The rapid development of vaccines to combat severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infections has been critical to reduce the severity of COVID-19 …

COVID-19 and lipids. The role of lipid disorders and statin use in the prognosis of patients with SARS-CoV-2 infection

S Surma, M Banach, J Lewek - Lipids in health and disease, 2021 - Springer
The global coronavirus disease 2019 (COVID-19) pandemic caused by the SARS-CoV-2
coronavirus started in March 2020. The conclusions from numerous studies indicate that …

[HTML][HTML] The SARS-CoV-2 spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces …

X Cao, V Nguyen, J Tsai, C Gao, Y Tian, Y Zhang… - Molecular …, 2023 - Elsevier
Background As the pandemic evolves, post-acute sequelae of CoV-2 (PASC) including
cardiovascular manifestations have emerged as a new health threat. This study aims to …

Uneven metabolic and lipidomic profiles in recovered COVID‐19 patients as investigated by plasma NMR metabolomics

M Bizkarguenaga, C Bruzzone… - NMR in …, 2022 - Wiley Online Library
COVID‐19 is a systemic infectious disease that may affect many organs, accompanied by a
measurable metabolic dysregulation. The disease is also associated with significant …

Reduced HDL-cholesterol in long COVID-19: A key metabolic risk factor tied to disease severity

J Al-Zadjali, A Al-Lawati, N Al Riyami, K Al Farsi… - Clinics, 2024 - SciELO Brasil
This controlled study investigated metabolic changes in non-vaccinated individuals with
Long-COVID-19, along with their connection to the severity of the disease. The study …

[HTML][HTML] The spike protein of sars-cov-2 impairs lipid metabolism and increases susceptibility to lipotoxicity: Implication for a role of nrf2

V Nguyen, Y Zhang, C Gao, X Cao, Y Tian, W Carver… - Cells, 2022 - mdpi.com
Coronavirus disease 2019 (COVID-19) patients show lipid metabolic alterations, but the
mechanism remains unknown. In this study, we aimed to investigate whether the Spike …

Efficacy and safety of metabolic interventions for the treatment of severe COVID-19: in vitro, observational, and non-randomized open-label interventional study

A Ehrlich, K Ioannidis, M Nasar, IA Alkian, Y Daskal… - Elife, 2023 - elifesciences.org
Background: Viral infection is associated with a significant rewire of the host metabolic
pathways, presenting attractive metabolic targets for intervention. Methods: We chart the …

[HTML][HTML] Incidence and predictors of development of new onset hypertension post COVID-19 disease

P Vyas, D Joshi, V Sharma, M Parmar, J Vadodariya… - Indian Heart …, 2023 - Elsevier
Aims The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 virus) affects vital
organs and causes vascular injury. There are concerns that this injury may have long-term …

Prognostic value of albumin-to-globulin ratio in COVID-19 patients: A systematic review and meta-analysis

JR Ulloque-Badaracco, MD Mosquera-Rojas… - Heliyon, 2022 - cell.com
Background and aims The albumin-to-globulin ratio (AGR) has been used to predict severity
and mortality in infectious diseases. The aim of this study is to evaluate the prognostic value …

Changes in serum liver function for patients with COVID-19: A 1-year follow-up study

X Zhu, J Wang, J Du, S Chen, S Chen… - Infection and Drug …, 2022 - Taylor & Francis
Objective Abnormal liver function and liver injury related to COVID-19 during hospitalization
has received widespread attention. However, the long-term observation of patients' liver …