Dopamine reuptake and inhibitory mechanisms in human dopamine transporter

Y Li, X Wang, Y Meng, T Hu, J Zhao, R Li, Q Bai… - Nature, 2024‏ - nature.com
The dopamine transporter has a crucial role in regulation of dopaminergic
neurotransmission by uptake of dopamine into neurons and contributes to the abuse …

Structure–Activity Relationship of Synthetic Cathinones: An Updated Review

N Nadal-Gratacós, MD Pazos, D Pubill… - ACS Pharmacology & …, 2024‏ - ACS Publications
The escalating prevalence of new psychoactive substances (NPSs) poses a significant
public health challenge, evidenced by the vast chemical diversity, with over 500 substances …

Ligand coupling mechanism of the human serotonin transporter differentiates substrates from inhibitors

R Gradisch, K Schlögl, E Lazzarin, M Niello… - Nature …, 2024‏ - nature.com
The presynaptic serotonin transporter (SERT) clears extracellular serotonin following
vesicular release to ensure temporal and spatial regulation of serotonergic signalling and …

Cocaine hydrochloride, cocaine methiodide and methylenedioxypyrovalerone (MDPV) cause distinct alterations in the structure and composition of the gut microbiota

M Angoa-Pérez, B Zagorac, DM Francescutti… - Scientific Reports, 2023‏ - nature.com
Cocaine is a highly addictive psychostimulant drug of abuse that constitutes an ongoing
public health threat. Emerging research is revealing that numerous peripheral effects of this …

Bioisosteric analogs of MDMA: Improving the pharmacological profile?

AS Alberto‐Silva, S Hemmer, HA Bock… - Journal of …, 2024‏ - Wiley Online Library
Methylenedioxymethamphetamine (MDMA,'ecstasy') is re‐emerging in clinical settings as a
candidate for the treatment of specific neuropsychiatric disorders (eg post‐traumatic stress …

Pharmacological profile, phase I metabolism, and excretion time profile of the new synthetic cathinone 3, 4‐Pr‐PipVP

HM Schwelm, M Persson, B Pulver… - Drug Testing and …, 2024‏ - Wiley Online Library
Abstract 1‐(2, 3‐Dihydro‐1H‐inden‐5‐yl)‐2‐(piperidin‐1‐yl) pentan‐1‐one (3, 4‐Pr‐PipVP),
a novel synthetic cathinone (SCat), was first identified in 2022 in Germany. The product was …

Structures of the dopamine transporter point to ways to target addiction and disease

HH Sitte - 2024‏ - nature.com
Structures of the dopamine transporter point to ways to target addiction and disease Skip to
main content Thank you for visiting nature.com. You are using a browser version with limited …

[HTML][HTML] Long-Lasting Epigenetic Changes in the Dopamine Transporter in Adult Animals Exposed to Amphetamine during Embryogenesis: Investigating Behavioral …

T Ke, G Ambigapathy, T Ton, A Dhasarathy… - International Journal of …, 2023‏ - mdpi.com
The dopamine transporter (DAT) is an integral member of the dopaminergic system and is
responsible for the release and reuptake of dopamine from the synaptic space into the …

Assessment of oxytocin and dopamine for the patients with post trumatic stress disorders

A Al-Kufaishi, NJT Al-Musawi - AIP conference proceedings, 2024‏ - pubs.aip.org
Background Throughout the past few decades, post-traumatic stress disorder (PTSD) has
received considerable attention from researchers in the fields of medicine, psychiatry …

Bioisosteric analogs of MDMA with improved pharmacological profile

AS Alberto-Silva, S Hemmer, HA Bock, L Alves da Silva… - bioRxiv, 2024‏ - biorxiv.org
Methylenedioxymethamphetamine (MDMA,'ecstasy') is re-emerging in clinical settings as a
candidate for the treatment of specific psychiatric disorders (eg post-traumatic stress …