Historically, the skin was thought to be a simple homogenous barrier. However, it is now
known to be a highly specialised organ, and plays a key role in homeostasis. The protective …

The effect and mode of action of aliphatic esters such as isopropyl myristate (IPM), which
were known as percutaneous absorption enhancers, on the in vitro permeation of a drug …

We have conducted permeation studies to assess the effectiveness of accelerants Azone,
oleic acid (OA), decylmethyl sulfoxide (DCMS) and propylene glycol (PG) in promoting the …

Chemical permeation enhancers (CPEs) are known to increase skin permeability to
therapeutic drugs. Single chemicals, however, offer limited enhancements of skin …

We have examined the effectiveness of pretreating human epidermis with a range of
accelerants on the permeation of model drugs 5-fluorouracil (5FU) and oestradiol (ES). To …

The purpose of this study was to determine the effects of ionization and penetration
enhancers on the transdermal delivery of 5-fluorouracil (5-FU) through excised human …

The potential usefulness of shed snake skin as a model membrane for transdermal research
was examined. There are similarities between shed snake skin and human stratum corneum …

The aim of the present paper was to investigate the promoting activity of borneol on the
transdermal permeation of drugs with differing lipophilicity, and probe its alterations in …

Purpose To calculate the skin concentration of active ingredients in cosmetics and topical
pharmaceuticals using silicone membrane permeation. Methods A series of parabens were …

In order to clarify the mechanism of action of laurocapram (Azone) on the skin permeation of
drugs, the following experiments were done. First, the effect of Azone on the skin …