Animal models of major depression: drawbacks and challenges

B Planchez, A Surget, C Belzung - Journal of Neural Transmission, 2019‏ - Springer
Major depression is a leading contributor to the global burden of disease. This situation is
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …

The rodent forced swim test measures stress-co** strategy, not depression-like behavior

KG Commons, AB Cholanians, JA Babb… - ACS chemical …, 2017‏ - ACS Publications
The forced swim test (FST) measures co** strategy to an acute inescapable stress and
thus provides unique insight into the neural limb of the stress response. Stress, particularly …

Cingulate dynamics track depression recovery with deep brain stimulation

S Alagapan, KS Choi, S Heisig, P Riva-Posse… - Nature, 2023‏ - nature.com
Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) can provide long-term
symptom relief for treatment-resistant depression (TRD). However, achieving stable recovery …

Deep brain stimulation for treatment-resistant depression: an integrative review of preclinical and clinical findings and translational implications

MP Dandekar, AJ Fenoy, AF Carvalho, JC Soares… - Molecular …, 2018‏ - nature.com
Although deep brain stimulation (DBS) is an established treatment choice for Parkinson's
disease (PD), essential tremor and movement disorders, its effectiveness for the …

WITHDRAWN: Adult hippocampal neurogenesis and antidepressants effects

B Planchez, A Surget, C Belzung - Current opinion in pharmacology, 2020‏ - Elsevier
WITHDRAWN: Adult hippocampal neurogenesis and antidepressants effects - ScienceDirect
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The role of glutamate underlying treatment-resistant depression

J Kim, TE Kim, SH Lee, JW Koo - Clinical …, 2023‏ - pmc.ncbi.nlm.nih.gov
The monoamine hypothesis has significantly improved our understanding of mood disorders
and their treatment by linking monoaminergic abnormalities to the pathophysiology of mood …

Harnessing neuroplasticity: modern approaches and clinical future

AO Sasmita, J Kuruvilla, APK Ling - International Journal of …, 2018‏ - Taylor & Francis
Background and purpose: Neurological diseases and injuries to the nervous system may
cause inadvertent damage to neuronal and synaptic structures. Such phenomenon would …

Whole brain network effects of subcallosal cingulate deep brain stimulation for treatment-resistant depression

J Cha, KS Choi, JK Rajendra, CL McGrath… - Molecular …, 2024‏ - nature.com
Ongoing experimental studies of subcallosal cingulate deep brain stimulation (SCC DBS) for
treatment-resistant depression (TRD) show a differential timeline of behavioral effects with …

In vivo brain sampling using a microextraction probe reveals metabolic changes in rodents after deep brain stimulation

N Reyes-Garcés, M Diwan, E Boyacı… - Analytical …, 2019‏ - ACS Publications
Brain metabolomics is an emerging field that complements the more traditional approaches
of neuroscience. However, typical brain metabolomics workflows require that animals be …

Neurogenesis-dependent antidepressant-like activity of Hericium erinaceus in an animal model of depression

PS Chong, CH Poon, J Roy, KC Tsui, SY Lew… - Chinese Medicine, 2021‏ - Springer
Background Depression is a severe neuropsychiatric disorder that affects more than 264
million people worldwide. The efficacy of conventional antidepressants are barely adequate …